Relationship between pulse wave velocity and serum YKL-40 level in patients with early rheumatoid arthritis

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dc.authoridDevrimsel, Gul/0000-0001-9775-6426
dc.authoridKarkucak, Murat/0000-0002-4348-8398
dc.contributor.authorTurkyilmaz, Aysegul Kucukali
dc.contributor.authorDevrimsel, Gul
dc.contributor.authorKirbas, Aynur
dc.contributor.authorCicek, Yuksel
dc.contributor.authorKarkucak, Murat
dc.contributor.authorCapkin, Erhan
dc.contributor.authorGokmen, Ferhat
dc.date.accessioned2025-01-27T20:22:54Z
dc.date.available2025-01-27T20:22:54Z
dc.date.issued2013
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractSubclinical atherosclerosis has been demonstrated in patients with early rheumatoid arthritis (ERA) without any signs of cardiovascular disease (CVD). The aim of this study was to investigate the relationship between serum YKL-40 level and arterial stiffness in patients with ERA. Forty two patients with ERA and 35 healthy controls with no history or current sign of CVD were included in the study. ERA patients with active disease, defined as DAS28 a parts per thousand yen3.2, and symptoms onset < 12 months were recruited. Arterial stiffness was evaluated by carotid-femoral pulse wave velocity (CF-PWV), and the intima-media thickness carotid (IMT-C) was measured by carotid ultrasonography. Serum YKL-40 levels were measured by an enzyme-linked immunoassay method. The mean age was 43.1 +/- A 5.8 years in ERA patients and 41.0 +/- A 5.9 years in control group. The CF-PWV and IMT-C of the ERA patients were determined significantly higher than the control group (P = .001, P < .001, respectively). YKL-40 levels were significantly elevated in ERA patients than controls (P = .008). The serum levels of YKL-40 in the ERA patients showed a strong correlation with CF-PWV (r = .711, P < .001) and IMT-C (r = .733, P < .001). Multiple linear regression analysis revealed that CF-PWV could be explained by serum YKL-40 levels (adjusted RA(2)A = .493, P < .001). We have shown that patients with ERA had increased CF-PWV and serum YKL-40 levels. In addition, there was an association between CF-PWV values and serum YKL-40 levels in patients with ERA. As a result, we believe that serum YKL-40 level and CF-PWV might reflect early atherosclerosis in patients with ERA.
dc.identifier.doi10.1007/s00296-013-2810-4
dc.identifier.endpage2756
dc.identifier.issn0172-8172
dc.identifier.issn1437-160X
dc.identifier.issue11
dc.identifier.pmid23797781
dc.identifier.scopus2-s2.0-84886675283
dc.identifier.scopusqualityQ1
dc.identifier.startpage2751
dc.identifier.urihttps://doi.org/10.1007/s00296-013-2810-4
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22067
dc.identifier.volume33
dc.identifier.wosWOS:000325962100007
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer Heidelberg
dc.relation.ispartofRheumatology International
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectYKL-40 level
dc.subjectArterial stiffness
dc.subjectCarotid-femoral pulse wave velocity
dc.subjectEarly rheumatoid arthritis
dc.titleRelationship between pulse wave velocity and serum YKL-40 level in patients with early rheumatoid arthritis
dc.typeArticle

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