Association between adiponectin and ADIPOQ (rs 1501299) gene polymorphism in gestational diabetes mellitus patients

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dc.contributor.authorCakina, Suat
dc.contributor.authorUlu, Selin
dc.contributor.authorBeyazit, Fatma
dc.contributor.authorOzen, Ebru
dc.contributor.authorPostaci, Emine Sevinc
dc.date.accessioned2025-01-27T20:39:07Z
dc.date.available2025-01-27T20:39:07Z
dc.date.issued2023
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIntroduction In this study, we seek to determine the association between the polymorphism of the ADIPOQ (rs1501299) gene and adiponectin levels in gestational diabetes mellitus (GDM) patients.Methods The study participants included 200 pregnant women, 100 healthy subjects as the control group, and 100 having GDM as the case group. The enzyme-linked immunosorbent assay (ELISA) was used to examine adiponectin levels. The polymerase chain reaction-restriction length polymorphism (PCR-RFLP) was also used for genotyping examination.Results Findings showed that GDM patients had significantly lower serum adiponectin levels (p=0.001). The T/T genotype ho-mozygotes prevalence for rs1501299 polymorphism was significantly lower in GDM patients. (p=0.047).Conclusion Low serum adiponectin levels are associated with GDM. The T allele of the rs1501299 (+276 G/T) polymorphism of the ADIPOQ gene protects against GDM.
dc.description.sponsorshipScientific Research Projects Coordination Unit of Cannakale Onsekiz Mart University [TSA-2019-3098]
dc.description.sponsorshipThis work has been supported by the Scientific Research Projects Coordination Unit of Cannakale Onsekiz Mart University. Project number: TSA-2019-3098.
dc.identifier.doi10.2478/rrlm-2023-0010
dc.identifier.endpage124
dc.identifier.issn1841-6624
dc.identifier.issn2284-5623
dc.identifier.issue2
dc.identifier.startpage119
dc.identifier.urihttps://doi.org/10.2478/rrlm-2023-0010
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23867
dc.identifier.volume31
dc.identifier.wosWOS:000981835400006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherSciendo
dc.relation.ispartofRevista Romana De Medicina De Laborator
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectgestational diabetes mellitus
dc.subjectadiponectin
dc.subjectpolymorphism
dc.titleAssociation between adiponectin and ADIPOQ (rs 1501299) gene polymorphism in gestational diabetes mellitus patients
dc.typeArticle

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