Association between adiponectin and ADIPOQ (rs 1501299) gene polymorphism in gestational diabetes mellitus patients
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Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Sciendo
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Introduction In this study, we seek to determine the association between the polymorphism of the ADIPOQ (rs1501299) gene and adiponectin levels in gestational diabetes mellitus (GDM) patients.Methods The study participants included 200 pregnant women, 100 healthy subjects as the control group, and 100 having GDM as the case group. The enzyme-linked immunosorbent assay (ELISA) was used to examine adiponectin levels. The polymerase chain reaction-restriction length polymorphism (PCR-RFLP) was also used for genotyping examination.Results Findings showed that GDM patients had significantly lower serum adiponectin levels (p=0.001). The T/T genotype ho-mozygotes prevalence for rs1501299 polymorphism was significantly lower in GDM patients. (p=0.047).Conclusion Low serum adiponectin levels are associated with GDM. The T allele of the rs1501299 (+276 G/T) polymorphism of the ADIPOQ gene protects against GDM.
Açıklama
Anahtar Kelimeler
gestational diabetes mellitus, adiponectin, polymorphism
Kaynak
Revista Romana De Medicina De Laborator
WoS Q Değeri
Q4
Scopus Q Değeri
Cilt
31
Sayı
2
