The effect of amifostine on bacterial translocation after radiation induced acute enteritis

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dc.contributor.authorTas, Sukru
dc.contributor.authorOzkul, Faruk
dc.contributor.authorArik, Muhammet Kasim
dc.contributor.authorKiraz, Asli
dc.contributor.authorVural, Ahmet
dc.date.accessioned2025-01-27T20:41:27Z
dc.date.available2025-01-27T20:41:27Z
dc.date.issued2016
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPURPOSE: To investigate the effects of amifostine on bacterial translocation and overgrowth in colonic flora after acute radiation enteritis in a rat model. METHODS: Thirty-two female Wistar albino rats were divided into four groups: Group-1 (n = 8): only normal saline was administered intraperitoneally. Group-2 (n = 8): first serum saline was administered intraperitoneally and 30 minutes later 20 Gy radiation was applied to abdominopelvic region. Group-3 (n = 8): only amifostine 200 ml/kg was administered intraperitoneally and radiation was not applied. Group-4 (n = 8): first amifostine 200 ml/kg was administered intraperitoneally and 30 minutes later 20 Gy radiation was applied to abdominopelvic region. On the 5th day after radiation, samples of mesenteric lymph tissues and cecal contents were taken by laparotomy for microbiological culture. RESULTS: Intraperitoneal amifostine administration significantly decreased the bacterial overgrowth related to radiation in colon but did not significantly decrease the bacterial translocation. CONCLUSION: Although not providing a full protection on the damaged mucosal barrier, amifostine significantly decreased the bacterial overgrowth in the cecal content after high dose radiation. There is a need to find out appropriate amifostine dose under different radiation applications avoiding bacterial translocation in gastrointestinal system.
dc.identifier.doi10.1590/S0102-865020160030000002
dc.identifier.endpage160
dc.identifier.issn0102-8650
dc.identifier.issn1678-2674
dc.identifier.issue3
dc.identifier.pmid27050785
dc.identifier.scopus2-s2.0-84962376956
dc.identifier.scopusqualityQ2
dc.identifier.startpage156
dc.identifier.urihttps://doi.org/10.1590/S0102-865020160030000002
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24146
dc.identifier.volume31
dc.identifier.wosWOS:000374189100002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherActa Cirurgica Brasileira
dc.relation.ispartofActa Cirurgica Brasileira
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectAmifostine
dc.subjectBacterial Translocation
dc.subjectEnteritis
dc.subjectRadiation
dc.subjectRats
dc.titleThe effect of amifostine on bacterial translocation after radiation induced acute enteritis
dc.typeArticle

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