The Impact of Lipoprotein Apheresis on Inflammatory Factors: A Systematic Review and Meta-Analysis

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dc.authorid0000-0002-0312-3773
dc.authorid0000-0003-4056-1673
dc.contributor.authorHatami, Alireza
dc.contributor.authorEslami, Masoud
dc.contributor.authorAslani, Saeed
dc.contributor.authorAlizadeh, Shahab
dc.contributor.authorSukhorukov, Vasily N.
dc.contributor.authorKarav, Sercan
dc.contributor.authorRazi, Bahman
dc.date.accessioned2026-02-03T12:03:18Z
dc.date.available2026-02-03T12:03:18Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractLipoprotein apheresis is a well-established therapy for patients with dyslipidemia unresponsive to conventional lipid-lowering strategies. However, its impact on systemic inflammation remains uncertain. This systematic review and meta-analysis evaluated the effect of apheresis on circulating inflammatory markers, including C-reactive protein (CRP), high-sensitivity CRP (hs-CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha). Following PRISMA guidelines, a systematic search of PubMed, Scopus, and ISI Web of Science was conducted up to June 2025. Studies reporting pre- and post-apheresis values for inflammatory markers were included. Standardized mean differences (SMD) and 95% confidence intervals (CI) were calculated. Thirteen publications met inclusion criteria. Meta-analysis demonstrated that apheresis significantly reduced CRP levels (SMD = -0.31; 95% CI: -0.44 to -0.18; p < 0.001), particularly in long-term interventions. No significant changes were observed for IL-6, TNF-alpha, or hs-CRP. In conclusion, apheresis significantly reduces CRP levels, especially with long-term treatment, suggesting a modest anti-inflammatory benefit. However, its effects on other markers remain unclear. Larger and high-quality trials are warranted.
dc.description.sponsorshipRussian Science Foundation [25-15-00269]
dc.description.sponsorshipThis work was supported by the Russian Science Foundation (25-15-00269).
dc.identifier.doi10.1002/jca.70082
dc.identifier.issn0733-2459
dc.identifier.issn1098-1101
dc.identifier.issue6
dc.identifier.pmid41383185
dc.identifier.scopus2-s2.0-105024656936
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1002/jca.70082
dc.identifier.urihttps://hdl.handle.net/20.500.12428/35007
dc.identifier.volume40
dc.identifier.wosWOS:001638113600001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Clinical Apheresis
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260130
dc.subjectapheresis
dc.subjectC-reactive protein
dc.subjecths-CRP
dc.subjectIL-6
dc.subjectinflammation
dc.subjectmeta-analysis
dc.subjectsystematic review
dc.subjectTNF-alpha
dc.titleThe Impact of Lipoprotein Apheresis on Inflammatory Factors: A Systematic Review and Meta-Analysis
dc.typeReview

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