Investigation of histopathological effects after intra-arterial sugammadex injection in an experimental animal model

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dc.authoriduzun, metehan/0000-0003-1406-5473
dc.authoridHanci, Volkan/0000-0002-2227-194X
dc.contributor.authorKiraz, H. A.
dc.contributor.authorToman, H.
dc.contributor.authorErbas, M.
dc.contributor.authorKarabulut, Yuyucu Y.
dc.contributor.authorSimsek, T.
dc.contributor.authorHanci, V
dc.contributor.authorUzun, M.
dc.date.accessioned2025-01-27T20:43:52Z
dc.date.available2025-01-27T20:43:52Z
dc.date.issued2016
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPURPOSE: Intra-arterial injection of medications are related to mortality and morbidity. It was aimed to investigate the histopathological effects caused by two different intra-arterial doses of sugammadex, a new selective relaxant binding agent used to reverse the effects of steroidal systemic muscle relaxants used in surgeries carried out under general anesthesia. METHODS: A total of 15 rabbits were randomly divided into 3 groups. The control group was given 1 mL saline bolus into the central artery of the ear. The other two groups (Group Sgdx2 and group Sgdx16) were given 2 and 16 mg/kg sugammadex, respectively, intra-arterially. RESULTS: In control group, histopathological evaluation was in normal limits. The cross-sections belonging to Group Sgdx2 did not have any significant pathological change compared with control group (p > 0.05). Edema and single-cell necrosis were significantly higher in Group Sgdx16 when compared to control group (p < 0.05). In comparison to Group Sgdx2, single-cell necrosis was significantly higher in Group Sgdx16 (p < 0.05). CONCLUSION: Being broadly used in anesthesia, sugammadex should be administered with care because when given by intra-arterial route it may cause tissue damage and tissue loss and the patients' arteries should be carefully checked (Tab. 2, Fig. 3, Ref. 21). Text in PDF www.elis.sk.
dc.identifier.doi10.4149/BLL_2016_058
dc.identifier.endpage298
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue5
dc.identifier.pmid27215966
dc.identifier.scopus2-s2.0-85014873333
dc.identifier.scopusqualityQ2
dc.identifier.startpage295
dc.identifier.urihttps://doi.org/10.4149/BLL_2016_058
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24405
dc.identifier.volume117
dc.identifier.wosWOS:000376813300010
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherComenius Univ
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listy
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectdose
dc.subjectexperimental
dc.subjectintra-arterial
dc.subjectrabbit
dc.subjectsugammadex
dc.titleInvestigation of histopathological effects after intra-arterial sugammadex injection in an experimental animal model
dc.typeArticle

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