Environmental epitranscriptomics

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dc.authoridByun, Hyang-Min/0000-0002-6278-3165
dc.authoridBarrow, Timothy/0000-0003-4551-3857
dc.contributor.authorCayir, Akin
dc.contributor.authorByun, Hyang-Min
dc.contributor.authorBarrow, Timothy M.
dc.date.accessioned2025-01-27T20:29:00Z
dc.date.available2025-01-27T20:29:00Z
dc.date.issued2020
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractChemical modifications of RNA molecules have gained increasing attention since evidence emerged for their substantive roles in a range of biological processes, such as the stability and translation of mRNA transcripts. More than 150 modifications have been identified in different organisms to date, collectively known as the 'epitranscriptome', with 6-methyladenosine (m(6)A), 5-methylcytidine (m(5)C), pseudouridine and N1-methyladenosine (m(1)A) the most extensively investigated. Although we are just beginning to elucidate the roles of these modifications in cellular functions, there is already evidence for their dysregulation in diseases such as cancer and neumdevelopmental disorders. There is currently more limited knowledge regarding how environmental exposures affect the epitranscriptome and how this may mediate disease risk, but evidence is beginning to emerge. Here, we review the current evidence for the impact of environmental exposures such as benzo[a]pyrene, bisphenol A, pesticides, metals and nanoparticles upon RNA modifications and the expression of their 'writers' (methyl transferases), 'erasers' (demethylases) and `readers'. We discuss future directions of the field and identify areas of particular promise and consider the technical challenges that are faced.
dc.description.sponsorshipScientific and Technological Research Council of Turkey [TUBITAK-115Z684]; COST (European Cooperation in Science and Technology) Action [CA16120]
dc.description.sponsorshipThis study was supported by The Scientific and Technological Research Council of Turkey (TUBITAK-115Z684) and by COST (European Cooperation in Science and Technology) Action CA16120. All authors read and approved the final manuscript.
dc.identifier.doi10.1016/j.envres.2020.109885
dc.identifier.issn0013-9351
dc.identifier.issn1096-0953
dc.identifier.pmid32979994
dc.identifier.scopus2-s2.0-85088033955
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.envres.2020.109885
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22769
dc.identifier.volume189
dc.identifier.wosWOS:000576644400007
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAcademic Press Inc Elsevier Science
dc.relation.ispartofEnvironmental Research
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectRNA modifications
dc.subjectEpitranscriptomics
dc.subjectEnvironmental exposure
dc.subjectm(6)A
dc.subjectm(1)A
dc.subjectm(5)C
dc.titleEnvironmental epitranscriptomics
dc.typeReview Article

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