Relationship between raised intraocular pressure and ischemia-modified albumin in serum and humor aqueous: a pilot study in rabbits

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dc.contributor.authorComez, Arza Taskiran
dc.contributor.authorCakir, Dilek Ulker
dc.contributor.authorTutunculer, Funda Kirtay
dc.contributor.authorGencer, Baran
dc.contributor.authorTufan, Hasan Ali
dc.date.accessioned2025-01-27T20:46:03Z
dc.date.available2025-01-27T20:46:03Z
dc.date.issued2014
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractAIM: To evaluate the relationship between increased intraocular pressure (IOP), ischemia-modified albumin levels in serum (IMA-s) and in humor aqueous (IMA-(HA)) in rabbits. METHODS: Twenty-five albino New Zealand rabbits weighing between 2.0 and 2.8 kg were used in this pilot study. With permission from Canakkale Onsekiz Mart University Animal Ethics Committee, the 10P of both eyes of each rabbit were recorded with a Tonopen (Tono-Pen XL, Reichart Inc., Depew, NY, USA) after the application of topical proparacaine 0.5% HCI anesthesia. Blood (4 mL) was collected from the marginal ear vein and an intracameral injection of 2.3 mg/mL sodium hyaluronate and subconjunctival dexamethasone was given in the right eye. Anterior chamber aqueous fluid was obtained using a timbal approach with a 27 gauge needle from both eyes. The left eyes were used as controls. 10P was measured on the 1st, 3rd and 10th day after the initial injection, with Tonopen, IMA -s levels and IMA -(HA) examined simultaneously. RESULTS: Before the injections, 10P was 11.4 +/- 3.0 mm Hg in the right eye and 11.3 +/- 3.1 mm Hg in the left eye (P> 0.05). There was a statistically significant difference between IMA-s levels before the IOP increase (IMA-s(o)) and IMA-s levels on the 1st and 3rd days after the increase in 10P (P=0.012 and P=0.01, respectively). No difference was observed between IMA -s(o) and serum IMA levels on the 10th day (IMA-s10) after IOP increase (P=0.989). IMA-HA in the right eye in the first day after the injection was positively correlated with 10P(gamma =0.748; P=0.02).No other correlation is found between any other parameter With IMA-Fik levels at any test time. A statistically significant positive correlation was observed between IMA-s values and 10P on the 1st and 3rd days(r =0.398, P =0.04 and r = 0.382, P =0.04, respectively). There was no correlation between IMA-s levels and increased 10P on the 10th day after kW increase (r =0.026, P =0.902). CONCLUSION: IMA may be an important indicator of acute damage caused by diseases involving ischemic damage to the eye, especially in case of increased intraocular pressure.
dc.description.sponsorshipCanakkale Onsekiz Mart University, Scientific Research Project Center [2010/206]
dc.description.sponsorshipSupported by Canakkale Onsekiz Mart University, Scientific Research Project Center (No.2010/206)
dc.identifier.doi10.3980/j.issn.2222-3959.2014.03.06
dc.identifier.endpage425
dc.identifier.issn2222-3959
dc.identifier.issn2227-4898
dc.identifier.issue3
dc.identifier.pmid24967184
dc.identifier.scopus2-s2.0-84903822307
dc.identifier.scopusqualityQ2
dc.identifier.startpage421
dc.identifier.urihttps://doi.org/10.3980/j.issn.2222-3959.2014.03.06
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24798
dc.identifier.volume7
dc.identifier.wosWOS:000337658400006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherIjo Press
dc.relation.ispartofInternational Journal of Ophthalmology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectischemia-modified albumin
dc.subjectintraocular pressure
dc.subjectserum
dc.subjecthumoi aqueous
dc.subjectrabbit
dc.subjecteye
dc.titleRelationship between raised intraocular pressure and ischemia-modified albumin in serum and humor aqueous: a pilot study in rabbits
dc.typeArticle

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