Affective Temperament Profiles in Patients with Multiple Sclerosis: Association with Mood Disorders

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dc.authoridKOC, EMINE RABIA/0000-0002-0264-7284
dc.contributor.authorOzkan, Adile
dc.contributor.authorAltinbas, Kursat
dc.contributor.authorKoc, Emine Rabia
dc.contributor.authorSen, Halil Murat
dc.contributor.authorKaraman, Handan Isin ozisik
dc.date.accessioned2025-01-27T20:25:00Z
dc.date.available2025-01-27T20:25:00Z
dc.date.issued2016
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIntroduction: The aim of the present study was to screen for bipolarity and to investigate the affective temperaments of patients with multiple sclerosis (MS) and the possible association between the clinical and demographic characteristics of MS patients and temperament profiles. Methods: A total of 65 patients with MS and 66 healthy volunteers completed the 32-item hypomania checklist (HCl-32), the Mood Disorder Questionnaire (MDQ), and the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego-Autoquestionnaire (TEMPS-A) tests. The HCl-32, MDQ, and TEMPS-A scores were compared between the patients and healthy volunteers. Results: MS patients had significantly higher scores for the depressive, cyclothymic, irritable, and anxious domains of the TEMPS-A scale than the control group, whereas relapsing remitting MS (RRMS) patients had higher MDQ and TEMPS-A hyperthymia scores than secondary progressive MS patients. MS patients who were being treated with interferon beta 1-b therapy had significantly higher MDQ scores than those being treated with interferon beta 1-a, glatiramer acetate, or who were without medication. Expanded Disability Status Scale (EDSS) scores were positively correlated with TEMPS-A depressive and hyperthymic temperaments. Conclusion: Our results suggest that higher scores for affective temperament in MS patients indicate subclinical manifestations of mood disorders. Higher hyperthymia scores and manic symptoms detected in the RRMS group could shed light on the relationship between bipolarity and MS. Thus, the screening of bipolarity and affective temperament profiles in MS patients could help clinicians predict future mood episodes and decrease their impact on disease severity.
dc.identifier.doi10.5152/npa.2015.12393
dc.identifier.endpage316
dc.identifier.issn1300-0667
dc.identifier.issn1309-4866
dc.identifier.issue4
dc.identifier.pmid28360804
dc.identifier.scopus2-s2.0-85006381854
dc.identifier.scopusqualityQ3
dc.identifier.startpage311
dc.identifier.urihttps://doi.org/10.5152/npa.2015.12393
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22407
dc.identifier.volume53
dc.identifier.wosWOS:000391572500005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkish Neuropsychiatry Assoc-Turk Noropsikiyatri Dernegi
dc.relation.ispartofNoropsikiyatri Arsivi-Archives of Neuropsychiatry
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectAffective temperament
dc.subjectbipolarity
dc.subjectmultiple sclerosis
dc.titleAffective Temperament Profiles in Patients with Multiple Sclerosis: Association with Mood Disorders
dc.typeArticle

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