Assessment of the genotoxic potential of a migraine-specific drug by comet and cytokinesis-block micronucleus assays

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dc.contributor.authorCayir, Akin
dc.contributor.authorCobanoglu, Hayal
dc.contributor.authorCoskun, Munevver
dc.date.accessioned2025-01-27T20:43:45Z
dc.date.available2025-01-27T20:43:45Z
dc.date.issued2020
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground: Eletriptan is a migraine-specific drug-containing the triptan group. In terms of drug safety, the present study aimed to investigate the genotoxic potential of eletriptan. Research design & methods: We conducted our study by using the cytokinesis-block micronucleus cytome (CBMN) assay, a comprehensive method for measuring micronucleus formation, and a sensitive method for detecting DNA-strand breaks. In the assay, cytokinesis-block proliferation index and the frequency of micronuclei were evaluated in lymphocytes treated with three different concentrations (1, 10 and 25 mu g/ml) of eletriptan for 48 hours. In comet assays, DNA damage was evaluated in leucocytes treated with three different concentrations (1, 10 and 25 mu g/ml) of eletriptan for an hour. Results: Eletriptan did not induce cytotoxicity nor any increased micronuclei frequencies. While the comet parameters % DNA in tail, tail moment, and the olive moment was found to be significantly increased at 10 and 25 mu g/ml, the cytokinesis-block proliferation index values were not. Conclusion: These findings suggest that eletriptan is non-cytotoxic but potentially weakly genotoxic at higher concentrations (10 and 25 mu g/ml).
dc.identifier.doi10.1080/17425255.2020.1748598
dc.identifier.endpage446
dc.identifier.issn1742-5255
dc.identifier.issn1744-7607
dc.identifier.issue5
dc.identifier.pmid32275455
dc.identifier.scopus2-s2.0-85083572329
dc.identifier.scopusqualityQ1
dc.identifier.startpage441
dc.identifier.urihttps://doi.org/10.1080/17425255.2020.1748598
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24362
dc.identifier.volume16
dc.identifier.wosWOS:000526303500001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofExpert Opinion on Drug Metabolism & Toxicology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectEletriptan
dc.subjectgenotoxicity
dc.subjectmigraine
dc.subjectcomet assay
dc.subjectmicronucleus
dc.titleAssessment of the genotoxic potential of a migraine-specific drug by comet and cytokinesis-block micronucleus assays
dc.typeArticle

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