Dose-dependent stress response of esfenvalerate insecticide on common carp (Cyprinus carpio): Evaluating blood parameters and gene expression

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dc.contributor.authorNavruz, Fahriye Zemheri
dc.contributor.authorAcar, Umit
dc.contributor.authorYılmaz, Sevdan
dc.contributor.authorKesbic, Osman Sabri
dc.date.accessioned2025-01-27T20:44:20Z
dc.date.available2025-01-27T20:44:20Z
dc.date.issued2023
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractEsfenvalerate is a pyrethroid insecticide used primarily in the agriculture sector for insect management. Esfenvalerate is effective against a wide range of harmful insects, including flies, cockroaches, locusts, and many other types of bugs. It is also known that esfenvalerate has toxic effects on aquatic organisms and poses significant environmental concerns. In this study, the aim is to subchronically examine the effects of sublethal concentrations of esfenvalerate insecticide on common carp (Cyprinus carpio) by assessing changes in blood parameters and resulting gene expression. For this purpose, common carp (Cyprinus carpio) were divided into 5 groups and exposed to 0.025, 0.05, 0.1, and 0.15 & mu;g/L concentrations of esfenvalerate for a period of 14 days. Blood and liver tissue samples were collected from the fish that underwent weight and length measurements. The effects on gene expression levels of immune, antioxidant, and stress-related genes in the liver tissue, including SOD, GST, Cortisol receptor, HSP70, H+-ATPase, Na+/K+-ATPase, Catalase, and GpX, were evaluated, as were the hematological and serum biochemical parameters. Significant decreases were observed in the levels of hematocrit, hemoglobin, erythrocytes, triglycerides and total protein and catalase, H+-ATPase, and GpX gene expression. Glucose, cholesterol, alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase (LDH) and alkaline phosphatase (ALP), SOD, Cortisol receptor, Na+/K+-ATPase gene expression levels increased. As a result, it has been revealed that esfenvalerate insecticide causes oxidative stress in carp at all dose ranges.
dc.description.sponsorshipBartin University Scientific Research Projects Coordination Unit [2021/03-10]
dc.description.sponsorshipAll the experimental procedures and the collection of samples were performed in compliance with the ethical considerations of the legislation on the protection of animals used for scientific purposes (Directive 2010/63) and also the current study was conducted with the approval of the local ethics committee for animal experiments, Canakkale Onsekiz Mart University, Canakkale, Turkey (Approval Number: 2021/03-10) . This work was supported by Bartin University Scientific Research Projects Coordination Unit. Project Number: 2021-FEN-B-006.
dc.identifier.doi10.1016/j.cbpc.2023.109711
dc.identifier.issn1532-0456
dc.identifier.issn1878-1659
dc.identifier.pmid37532111
dc.identifier.scopus2-s2.0-85166595242
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.cbpc.2023.109711
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24542
dc.identifier.volume272
dc.identifier.wosWOS:001071816100001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Inc
dc.relation.ispartofComparative Biochemistry and Physiology C-Toxicology & Pharmacology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectEsfenvalerate
dc.subjectCyprinus carpio
dc.subjectGene expression
dc.subjectOxidative stress
dc.titleDose-dependent stress response of esfenvalerate insecticide on common carp (Cyprinus carpio): Evaluating blood parameters and gene expression
dc.typeArticle

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