Inflammation and chemerin in colorectal cancer

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dc.authoridSendur, Mehmet/0000-0001-7021-6139
dc.contributor.authorErdogan, Serpil
dc.contributor.authorYilmaz, Fatma Meric
dc.contributor.authorYazici, Ozan
dc.contributor.authorYozgat, Ahmet
dc.contributor.authorSezer, Sevilay
dc.contributor.authorOzdemir, Nuriye
dc.contributor.authorUysal, Sema
dc.date.accessioned2025-01-27T20:24:19Z
dc.date.available2025-01-27T20:24:19Z
dc.date.issued2016
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractChemerin is expressed mainly in the adipose tissue. It is an agonist of chemokine-like receptor-1, which is expressed by the immune system cells. Chemerin stimulates the chemotaxis of the immune system cells, and this indicates the function of chemerin and chemokine-like receptor-1 in the immune response. The tumor microenvironment is very important for determining cancer cell growth and spreading. Therefore, we aimed to investigate the association between colorectal cancer, inflammation, and adipokines including chemerin, adiponectin, and vaspin. The study group consisted of patients with colon cancer, whereas the control subjects consisted of patients with benign conditions, diagnosed with colonoscopy. The two groups were compared in terms of the C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), fibrinogen, adiponectin, chemerin, and vaspin. A total of 41 (28 men, 13 women) patients with confirmed colon cancer, and 27 (15 men, 12 women) controls without, confirmed by colonoscopy, were enrolled. The median chemerin levels were found significantly higher in the study group than the controls (390 vs. 340 ng/mL, p=0.032), whereas the mean vaspin and adiponectin levels were not significantly different. The median values for the CRP, fibrinogen, and ESR were significantly higher in the patients with colon cancer, when compared to the control group (6.08 vs. 1.4 mg/L, p<0.0001; 408 vs. 359 mg/dL, p=0.002; and 30 vs. 8 mm/h, p<0.0001, respectively). Our results show that higher levels of circulating chemerin, CRP, fibrinogen, and ESR are associated with an increased risk of developing colorectal cancer.
dc.description.sponsorshipAnkara Numune Training and Research Hospital [492/2012]
dc.description.sponsorshipThis study is supported by the Ankara Numune Training and Research Hospital (grant number 492/2012).
dc.identifier.doi10.1007/s13277-015-4483-y
dc.identifier.endpage6342
dc.identifier.issn1010-4283
dc.identifier.issn1423-0380
dc.identifier.issue5
dc.identifier.pmid26628300
dc.identifier.scopus2-s2.0-84949510054
dc.identifier.scopusqualityQ3
dc.identifier.startpage6337
dc.identifier.urihttps://doi.org/10.1007/s13277-015-4483-y
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22157
dc.identifier.volume37
dc.identifier.wosWOS:000376465800076
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSage Publications Ltd
dc.relation.ispartofTumor Biology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectColorectal cancer
dc.subjectC-reactive protein
dc.subjectInflammation
dc.subjectFibrinogen
dc.subjectErythrocyte sedimentation rate
dc.subjectChemerin
dc.titleInflammation and chemerin in colorectal cancer
dc.typeArticle

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