Antimicrobial susceptibility and resistance mechanisms of methicillin resistant Staphylococcus aureus isolated from 12 Hospitals in Turkey

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dc.authoridozkutuk, nuri/0000-0002-2848-5914
dc.authoridARSLAN, UGUR/0000-0001-6974-9173
dc.authoridBOZDOGAN, BULENT/0000-0003-2469-9728
dc.contributor.authorYildiz, Omer
dc.contributor.authorCoban, Ahmet Yilmaz
dc.contributor.authorSener, Asli Gamze
dc.contributor.authorCoskuner, Seher Ayten
dc.contributor.authorBayramoglu, Gulcin
dc.contributor.authorGuducuoglu, Huseyin
dc.contributor.authorOzyurt, Mustafa
dc.date.accessioned2025-01-27T21:01:46Z
dc.date.available2025-01-27T21:01:46Z
dc.date.issued2014
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIntroduction: Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most important nosocomial pathogens and is also emerging in Turkish hospitals. The aim of this study was to determine the antimicrobial susceptibility profiles of MRSA isolated from Turkish hospitals. Materials and methods: A total of 397 MRSA strains isolated from 12 hospitals in Turkey were included to present study. Antimicrobial susceptibilities were tested using agar dilution method. Presence of ermA, ermB, ermC, msrA, tetM, tetK, linA and aac-aph genes were studied by PCR. Results: All strains were susceptible to vancomycin and linezolid. The susceptibility rates for fusidic acid, lincomycin, erythromycin, tetracyclin, gentamycin, kanamycin, and, ciprofloxacin were 91.9%, 41.1%, 27.2%, 11.8%, 8.5%, 8.3% and 6.8%, respectively. Lincomycin inactivation was positive for 3 isolates. Of 225 erythromycin resistant isolates 48 had ermA, 20 had ermC, and 128 had ermA-C. PCR was negative for 15 strains. Of 3 isolates with lincomycin inactivation one had linA and msrA. Of 358 gentamycin resistant isolates 334 had aac-aph and 24 were negatives. Among 350 tetracyclin resistant isolates 314 had tetM. Of 36 tetM negative isolates 10 had tetK. Conclusion: MRSA isolates from Turkish hospitals were multiresistant to antimicrobials. Quinolone and gentamycin resistance levels were high and macrolide and lincosamide resistance were relatively low. Susceptibility rates for fusidic asid were high. Linezolide and vancomycin resistance are not emerged. The most common resistance genes were ermA, tetM and aac-aph. Evolution of antimicrobial susceptibilities and resistance genes profiles of MRSA isolates should be surveyed at regional and national level for accurate treatment of patients and to control dissemination of resistance genes.
dc.description.sponsorshipAdnan Menderes University BAP [TPF09025]
dc.description.sponsorshipThis study was supported by grant TPF09025 from Adnan Menderes University BAP.
dc.identifier.doi10.1186/s12941-014-0044-2
dc.identifier.issn1476-0711
dc.identifier.pmid25223381
dc.identifier.scopus2-s2.0-84908119370
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1186/s12941-014-0044-2
dc.identifier.urihttps://hdl.handle.net/20.500.12428/27181
dc.identifier.volume13
dc.identifier.wosWOS:000342093000001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBiomed Central Ltd
dc.relation.ispartofAnnals of Clinical Microbiology and Antimicrobials
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectStaphylococci
dc.subjectMRSA
dc.subjectAntimicrobial susceptibility
dc.subjectResistance mechanisms
dc.subjectPCR
dc.titleAntimicrobial susceptibility and resistance mechanisms of methicillin resistant Staphylococcus aureus isolated from 12 Hospitals in Turkey
dc.typeArticle

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