A comparison of the effects of N-acetylcysteine and ethyl pyruvate on experimental testicular ischemia-reperfusion injury

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dc.authoridKARACA, YUNUS/0000-0002-0947-0565
dc.authoridTuredi, Suleyman/0000-0002-6500-3961
dc.authoridTurkmen, Suha/0000-0002-0557-6071
dc.authoridYulug, Esin/0000-0002-8857-9234
dc.authoridKaraguzel, Ersagun/0000-0003-4270-0147
dc.contributor.authorTurkmen, Suha
dc.contributor.authorMentese, Ahmet
dc.contributor.authorKaraguzel, Ersagun
dc.contributor.authorKaraca, Yunus
dc.contributor.authorKucuk, Adem
dc.contributor.authorUzun, Aysegul
dc.contributor.authorYulug, Esin
dc.date.accessioned2025-01-27T20:45:40Z
dc.date.available2025-01-27T20:45:40Z
dc.date.issued2012
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: To compare the effects of N-acetylcysteine (NAC) and ethyl pyruvate (EP) on experimental testicular ischemia-reperfusion (I/R) injury. Design: Randomized, controlled, experimental study. Setting: University hospital. Animal(s): Twenty-four mature male Wistar rats. Intervention(s): Rats were divided into four groups: control group, torsion-detorsion (T/D) group, EP group, and NAC group. In the pretreatment of the NAC and EP groups, 20 mg/kg NAC and 50 mg/kg EP were given intraperitoneally (IP) 30 minutes before detorsion. Main Outcome Measure(s): Serum ischemia-modified albumin (IMA), tissue and serum malondialdehyde, and myeloperoxidase activity levels and histopathological damage scores were then compared. Result(s): Ethyl pyruvate and N-acetylcysteine exhibited a protective effect against I/R injury. Of the biochemical parameters evaluated as a result of testicular I/R, only IMA levels were significantly elevated. There was a strong and significant correlation between serum IMA levels and histopathological injury scores, and the increase in serum IMA level exhibited a strong parallel with the increase in histopathological injury. In the EP group, although the histopathological injury score was similar to that of the control group, serum IMA levels were significantly elevated. Conclusion(s): Both NAC and EP, the effects of which on I/R injury are evaluated in the present study, reduce such injury in testicular torsion-detorsion. Comparing their effects on IMA levels, NAC may be regarded as a relatively more effective treatment than EP. (Fertil Steril (R) 2012; 98: 626-31. (C) 2012 by American Society for Reproductive Medicine.)
dc.identifier.doi10.1016/j.fertnstert.2012.05.034
dc.identifier.endpage631
dc.identifier.issn0015-0282
dc.identifier.issue3
dc.identifier.pmid22717346
dc.identifier.scopus2-s2.0-84865681322
dc.identifier.scopusqualityQ1
dc.identifier.startpage626
dc.identifier.urihttps://doi.org/10.1016/j.fertnstert.2012.05.034
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24676
dc.identifier.volume98
dc.identifier.wosWOS:000308402400026
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Inc
dc.relation.ispartofFertility and Sterility
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectEthyl pyruvate
dc.subjectischemia-reperfusion injury
dc.subjectischemia-modified albumin
dc.subjectN-acetylcysteine
dc.subjecttesticular torsion-detorsion
dc.titleA comparison of the effects of N-acetylcysteine and ethyl pyruvate on experimental testicular ischemia-reperfusion injury
dc.typeArticle

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