Effect of Smoking on Tp-e Interval, Tp-e/QT and Tp-e/QTc Ratios as Indices of Ventricular Arrhythmogenesis

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dc.contributor.authorTasolar, Hakan
dc.contributor.authorBalli, Mehmet
dc.contributor.authorBayramoglu, Adil
dc.contributor.authorOtlu, Yilmaz Omur
dc.contributor.authorCetin, Mustafa
dc.contributor.authorAltun, Burak
dc.contributor.authorCakici, Musa
dc.date.accessioned2025-01-27T20:20:42Z
dc.date.available2025-01-27T20:20:42Z
dc.date.issued2014
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground Smoking may lead to ventricular arrhythmias and sudden cardiac death via altering ventricular recovery time dispersion indices such as QT interval and QT dispersion (QTd). The Tp-e/QT and Tp-e/QTc ratios are also known as predictors of ventricular arrhythmogenesis. The aim of this study was to evaluate the relationship between cigarette smoking and ventricular repolarisation dispersion using these novel electrocardiographic parameters. Methods One hundred and twenty-one chronic smokers and 70 age- and sex-matched non-smoker controls were included in our study. The Tp-e interval and Tp-e/QT ratio were measured by 12-lead electrocardiogram, and corrected for heart rate. Results QTd (34.2 +/- 8.4, 27.2 +/- 10.4, P < 0.001) and corrected QTd (37.3 +/- 8.9, 29.8 +/- 11.2, P < 0.001) were significantly increased in the smokers compared to the non-smoker control group. The Tp-e interval (76.5 +/- 6.3, 70.3 +/- 6.8, P < 0.001), cTp-e interval (83.5 +/- 8.0, 77.1 +/- 8.7, P <0.001), Tp-e/QT (0.20 +/- 0.03, 0.19 +/- 0.02, P < 0.001) and Tp-e/QTc ratios (0.19 +/- 0.02, 0.17 +/- 0.02, P < 0.001) were increased in the patient group when compared to the controls. Significant positive correlations were also found between the level of smoking with the cTp-e interval (r = 0.836, P <0.001), and Tp-e/QT (r = 0.714, P <0.001) and Tp-e/QTc ratios (r = 0.448, P < 0.001). Conclusion We found in our study that cTp-e interval, Tp-e/QT and Tp-e/QTc ratios were increased in smokers and significantly correlated to the amount of smoking.
dc.identifier.doi10.1016/j.h1c.2014.03.016
dc.identifier.endpage832
dc.identifier.issn1443-9506
dc.identifier.issn1444-2892
dc.identifier.issue9
dc.identifier.pmid24746776
dc.identifier.scopus2-s2.0-84923780878
dc.identifier.scopusqualityQ2
dc.identifier.startpage827
dc.identifier.urihttps://doi.org/10.1016/j.h1c.2014.03.016
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21788
dc.identifier.volume23
dc.identifier.wosWOS:000341473900007
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Inc
dc.relation.ispartofHeart Lung and Circulation
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectSmokers
dc.subjectNicotine
dc.subjectTp-e interval
dc.subjectTp-e/QT ratio
dc.subjectVentricular arrhythmogenesis
dc.titleEffect of Smoking on Tp-e Interval, Tp-e/QT and Tp-e/QTc Ratios as Indices of Ventricular Arrhythmogenesis
dc.typeArticle

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