Changes in the Pancreas in Experimental Diabetes and the Effect of Lycopene on These Changes: Proliferating, Apoptotic, and Estrogen Receptor a Positive Cells

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dc.authoridSANDIKCI, MUSTAFA/0000-0002-9126-1016
dc.authoridYıldız, Mustafa/0000-0003-4128-8947
dc.authoridKaragenc, Levent/0000-0003-2074-2450
dc.contributor.authorSandikci, Mustafa
dc.contributor.authorKaragenc, Levent
dc.contributor.authorYıldız, Mustafa
dc.date.accessioned2025-01-27T20:49:41Z
dc.date.available2025-01-27T20:49:41Z
dc.date.issued2017
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThis study aimed to investigate the changes occurring in estrogen receptor ( ER) alpha-positive cells, proliferating cells, apoptotic cells and malondialdehyde ( MDA) expression in the pancreas of experimentally induced adult diabetic rats and to determine the effect of orally administered lycopene on these changes. Experimental diabetes was induced using a single dose of 50 mg/kg streptozotocin ( STZ). Following the administration of STZ, four groups of animals were established: Control1corn oil, control1lycopene, diabetic1corn oil and diabetic1lycopene. The expressions of ER a, Ki-67, and MDA were determined through immunohistochemistry in sections taken from pancreas tissue samples at the end of the experiment. Apoptotic cells were determined through the TUNEL method. In the diabetic groups, the densities of ER a expression in islets and ER alpha-positive cells in exocrine parts increased. Whereas the number of proliferating Ki-67 positive cells was higher in the diabetic groups, no significant difference was observed in terms of apoptotic cell number between the control and diabetic groups. Lycopene in general did not have any effect on any of the parameters analyzed in the study. The presence of ER alpha-positive cells around the islets was demonstrated for the first time in diabetic groups. Based on these observations, demonstrating the antioxidant effects of lycopene in the pancreas of diabetic rats may be possible by increasing the dose and/or the duration of lycopene. Anat Rec, 300:2000-2007, 2017. (C) 2017 Wiley Periodicals, Inc.
dc.description.sponsorshipAdnan Menderes University [VTF-13005]
dc.description.sponsorshipThis study was supported by a research fund from Adnan Menderes University. Project no: VTF-13005. Also, the study was presented as a poster presentation at the 13th National Congress of Histology and Embryology, April 30-May 03 2016, Cesme/Izmir, Turkey.
dc.identifier.doi10.1002/ar.23641
dc.identifier.endpage2007
dc.identifier.issn1932-8486
dc.identifier.issn1932-8494
dc.identifier.issue11
dc.identifier.pmid28681493
dc.identifier.scopus2-s2.0-85024128800
dc.identifier.scopusqualityQ1
dc.identifier.startpage2000
dc.identifier.urihttps://doi.org/10.1002/ar.23641
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25278
dc.identifier.volume300
dc.identifier.wosWOS:000412087200010
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofAnatomical Record-Advances in Integrative Anatomy and Evolutionary Biology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectexperimental diabetes
dc.subjectpancreas
dc.subjectestrogen receptor alpha
dc.subjectproliferating cell
dc.subjectlycopene
dc.titleChanges in the Pancreas in Experimental Diabetes and the Effect of Lycopene on These Changes: Proliferating, Apoptotic, and Estrogen Receptor a Positive Cells
dc.typeArticle

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