DNA- Binding, Biological Activities, and Chemical Composition of Wild

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dc.contributor.authorSayık, Aysema
dc.contributor.authorYusufoğlu, Ayşe Sergüzel
dc.contributor.authorAçık, Leyla
dc.contributor.authorTürker, Gülen
dc.contributor.authorArslan, Leyla
dc.date.accessioned2025-01-27T19:45:33Z
dc.date.available2025-01-27T19:45:33Z
dc.date.issued2017
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThe usage of Epilobium angustifolium L. in folk medicine against prostate and dermal diseases encouraged us to investigate pBR322 DNA-binding ability, biological activities and chemical composition of wild growing Epilobium angustifolium L.’s methanolic, ethanolic and aqueous extracts from Canakkale, Turkey. DNA-binding activity was studied by agarose gel electrophoresis and chemical composition via GC, GC-MS, HPLC, LC-MS, ICP-MS, and AAS. A detailed literature survey indicates no data on pBR322 plasmid DNA interaction of Epilobium species which is an important criterion for being a potential anticancer agent. Antibacterial and antifungal effects were tested against 11 bacteria and 3 fungi and compared with ampicillin, chloramphenicol, and ketoconazole by agar well diffusion techniques. Total phenolic content was found by Folin-Ciocalteu method, and antioxidant activity was obtained by DPPH and Fe(II)-FZ (ferric-ferrozine) methods. This plant is rich in flavonoids, hormones, fatty acids, and phenolic acids. Si, K, Mg, P, and Mn were the main inorganic elements. Epilobium angustifolium L. with its high DNA-binding activity and rich chemical composition can be an excellent potential anticancer, antimicrobial and antioxidant prodrug
dc.identifier.endpage840
dc.identifier.issn2149-0120
dc.identifier.issue3
dc.identifier.startpage811
dc.identifier.trdizinid257189
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/257189
dc.identifier.urihttps://hdl.handle.net/20.500.12428/18349
dc.identifier.volume4
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofJournal of the Turkish Chemical Society, Section A: Chemistry
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TRD_20250125
dc.subjectBiyoloji
dc.subjectKimya
dc.subjectAnalitik
dc.subjectKimya
dc.subjectUygulamalı
dc.titleDNA- Binding, Biological Activities, and Chemical Composition of Wild
dc.typeArticle

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