DNA- Binding, Biological Activities, and Chemical Composition of Wild
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Tarih
2017
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The usage of Epilobium angustifolium L. in folk medicine against prostate and dermal diseases encouraged us to investigate pBR322 DNA-binding ability, biological activities and chemical composition of wild growing Epilobium angustifolium L.’s methanolic, ethanolic and aqueous extracts from Canakkale, Turkey. DNA-binding activity was studied by agarose gel electrophoresis and chemical composition via GC, GC-MS, HPLC, LC-MS, ICP-MS, and AAS. A detailed literature survey indicates no data on pBR322 plasmid DNA interaction of Epilobium species which is an important criterion for being a potential anticancer agent. Antibacterial and antifungal effects were tested against 11 bacteria and 3 fungi and compared with ampicillin, chloramphenicol, and ketoconazole by agar well diffusion techniques. Total phenolic content was found by Folin-Ciocalteu method, and antioxidant activity was obtained by DPPH and Fe(II)-FZ (ferric-ferrozine) methods. This plant is rich in flavonoids, hormones, fatty acids, and phenolic acids. Si, K, Mg, P, and Mn were the main inorganic elements. Epilobium angustifolium L. with its high DNA-binding activity and rich chemical composition can be an excellent potential anticancer, antimicrobial and antioxidant prodrug
Açıklama
Anahtar Kelimeler
Biyoloji, Kimya, Analitik, Kimya, Uygulamalı
Kaynak
Journal of the Turkish Chemical Society, Section A: Chemistry
WoS Q Değeri
Scopus Q Değeri
Cilt
4
Sayı
3
