Attenuation of partial unilateral ureteral obstruction - induced renal damage with hyperbaric oxygen therapy in a rat model

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dc.authoridSılan, Coşkun/0000-0002-8352-6571
dc.contributor.authorSancak, Eyup Burak
dc.contributor.authorTan, Yusuf Ziya
dc.contributor.authorTurkon, Hakan
dc.contributor.authorSılan, Coşkun
dc.date.accessioned2025-01-27T20:41:03Z
dc.date.available2025-01-27T20:41:03Z
dc.date.issued2017
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: The objective of the present study was to evaluate the effectiveness of HBO therapy on biochemical parameters, renal morphology and renal scintigraphy in rats undergoing chronic unilateral partial ureteral obstruction (UPUO). Material and methods: Thirty-five rats were divided into five equal groups: Control group; Sham group; HBO group; UPUO group and UPUO/HBO group. The effects of HBO therapy were examined using biochemical parameters and histopathological changes. After calculating the score for each histopathological change, the total histopathological score was obtained by adding all the scores. In addition, dynamic renal scintigraphy findings were evaluated. Results: Serum parameters indicating inflammation, serum tumor necrosis factoralpha, ischemia modified-albumin, IMA/albumin ratio and Pentraxin-3 levels, were observed to be high in the UPUO group and low in the UPUO/HBO treatment group. Similarly, in the treatment group, the reduction in malondialdehyde, total oxidant status and oxidative stress index levels and increase in total antioxidant capacity values were observed to be statistically significant compared to the UPUO group (p< 0.001, p= 0.007, p< 0.001, p= 0.001, respectively). The total score and apoptosis index significantly decreased after administration of HBO treatment. Dynamic 99mTc-MAG3 renal scintigraphy also showed convincing evidence regarding the protective nature of HBO against kidney injury. In the UPUO/HBO therapy group, the percentage contribution of each operated kidney increased significantly compared to the UPUO group (41.73% versus 32.72%). Conclusion: The findings of this study indicate that HBO therapy had a reno-protective effect by reducing inflammation and oxidative stress, and preserving renal function after renal tissue damage due to induction of UPUO.
dc.description.sponsorshipResearch Fund of Canakkale Onsekiz Mart University [TSA-2015-459]
dc.description.sponsorshipThis study was funded by the Research Fund of Canakkale Onsekiz Mart University. Project Number: TSA-2015-459.
dc.identifier.doi10.1590/S1677-5538.IBJU.2016.0565
dc.identifier.endpage956
dc.identifier.issn1677-5538
dc.identifier.issn1677-6119
dc.identifier.issue5
dc.identifier.pmid28191789
dc.identifier.scopus2-s2.0-85033366214
dc.identifier.scopusqualityQ2
dc.identifier.startpage946
dc.identifier.urihttps://doi.org/10.1590/S1677-5538.IBJU.2016.0565
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23993
dc.identifier.volume43
dc.identifier.wosWOS:000417397100022
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBrazilian Soc Urol
dc.relation.ispartofInternational Braz J Urol
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectHyperbaric Oxygenation
dc.subjectUreteral Obstruction
dc.subjectApoptosis
dc.titleAttenuation of partial unilateral ureteral obstruction - induced renal damage with hyperbaric oxygen therapy in a rat model
dc.typeArticle

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