Endothelial function and germ-line ACE I/D, eNOS and PAI-1 gene profiles in patients with coronary slow flow in the Canakkale population: multiple thrombophilic gene profiles in coronary slow flow

Basit Öğe Kaydı
dc.contributor.authorGazi, Emine
dc.contributor.authorTemiz, Ahmet
dc.contributor.authorAltun, Burak
dc.contributor.authorBarutcu, Ahmet
dc.contributor.authorSılan, Fatma
dc.contributor.authorColkesen, Yucel
dc.contributor.authorÖzdemir, Öztürk
dc.date.accessioned2025-01-27T20:47:31Z
dc.date.available2025-01-27T20:47:31Z
dc.date.issued2014
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground: We examined the effects of ACE, PAI-1 and eNOS gene polymorphisms on endothelial function. The genes are related to atherosclerosis and endothelial dysfunction in coronary slow flow (CSF). Methods: Thirty-three patients with angiographically proven CSF and 48 subjects with normal coronary flow were enrolled in this study. Coronary flow patterns were determined by the thrombolysis in myocardial infarction (TIMI) frame count method. Endothelial function was assessed in the brachial artery by endothelium-dependent flow-mediated dilatation (FMD). PAI-1 4G/5G, eNOS T-786C and ACE I/D polymorphisms were determined by polymerase chain reaction (PCR) amplification. Results: No difference was found between the groups regarding age, heart rate and blood pressure. Males were more prevalent among patients with CSF than control subjects (58.8 vs 29.8%, p = 0.009). Mean TIMI frame counts were significantly higher in CSF patients (24.2 +/- 4.0 vs 13.1 +/- 2.5 fpm, p = 0.001). FMD was significantly lower in CSF patients than in the controls (4.9 +/- 6.6 vs 7.9 +/- 5.6%, p = 0.029). TIMI frame count and FMD were found to be negatively correlated in a correlation analysis (r = -0.269, p = 0.015). PAI-1 4G/5G, eNOS T-786C and ACE I/D polymorphisms were similar in the two groups. Conclusions: This study showed that endothelial function was impaired in patients with CSF. PAI-1, ACE and eNOS polymorphisms were not related to CSF in our study population.
dc.identifier.doi10.5830/CVJA-2013-083
dc.identifier.endpage14
dc.identifier.issn1995-1892
dc.identifier.issn1680-0745
dc.identifier.issue1
dc.identifier.pmid24435163
dc.identifier.scopus2-s2.0-84897545566
dc.identifier.scopusqualityQ3
dc.identifier.startpage9
dc.identifier.urihttps://doi.org/10.5830/CVJA-2013-083
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24942
dc.identifier.volume25
dc.identifier.wosWOS:000343278200004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherClinics Cardive Publ Pty Ltd
dc.relation.ispartofCardiovascular Journal of Africa
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectthrombophilic genes
dc.subjectSNP
dc.subjectPAI-1 4G/5G
dc.subjecteNOS T-786C
dc.subjectACE I/D
dc.subjectcoronary slow flow
dc.titleEndothelial function and germ-line ACE I/D, eNOS and PAI-1 gene profiles in patients with coronary slow flow in the Canakkale population: multiple thrombophilic gene profiles in coronary slow flow
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu