Molecular weight dependent antistaphylococcal activities of oligomers/polymers synthesized from 3-aminopyridine

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dc.contributor.authorAkgul, Cahit
dc.contributor.authorYildirim, Mehmet
dc.date.accessioned2025-01-27T20:14:12Z
dc.date.available2025-01-27T20:14:12Z
dc.date.issued2010
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThe main aim of this study was to investigate the relationship between molecular weight and the antistaphylococcal activity of oligomers/polymers synthesized from 3-aminopyridine. Different oligomers/polymers were synthesized from 3-aminopyridine by changing the oxidative polycondensation reaction conditions. They were characterized by size exclusion chromatography and their antibacterial activities were compared by employing standardized susceptibility assays. The obtained experimental results demonstrated that 3-aminopyridine had no antistaphylococcal activity. However, as a result of polymerization, strong antistaphylococcal activity was obtained. Oligomers/polymers synthesized from 3-aminopyridine had varying degrees of antistaphylococcal activity and the maximum activity was obtained from relatively very short oligomers. It was therefore concluded that polymerization of 3-aminopyridine is required for antistaphylococcal activity and strength of this activity depends on the molecular weights of the synthesized molecules.
dc.description.sponsorshipCOMU Scientific Research Projects Commission [2008/75]
dc.description.sponsorshipThe authors thank Dilek Bahceci for technical assistance in the SEC analyses. Funding: COMU Scientific Research Projects Commission (Project No.: 2008/75)
dc.identifier.doi10.2298/JSC100201104A
dc.identifier.endpage1208
dc.identifier.issn0352-5139
dc.identifier.issue9
dc.identifier.scopus2-s2.0-77958597636
dc.identifier.scopusqualityQ3
dc.identifier.startpage1203
dc.identifier.urihttps://doi.org/10.2298/JSC100201104A
dc.identifier.urihttps://hdl.handle.net/20.500.12428/20989
dc.identifier.volume75
dc.identifier.wosWOS:000283207200004
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSerbian Chemical Soc
dc.relation.ispartofJournal of The Serbian Chemical Society
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectantibacterial
dc.subject3-aminopyridine
dc.subjectoligomer
dc.subjectStaphylococcus aureus
dc.titleMolecular weight dependent antistaphylococcal activities of oligomers/polymers synthesized from 3-aminopyridine
dc.typeArticle

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