Increased Sister Chromatid Exchanges in Patients with Gastrointestinal Cancers and in their First-Degree Relatives

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dc.authoridYaykasli, Kursat/0000-0001-7550-6370
dc.contributor.authorTurgut, Taner
dc.contributor.authorYasar, Mehmet
dc.contributor.authorYaykasli, Kursat Oguz
dc.contributor.authorErtas, Ertugrul
dc.contributor.authorSılan, Fatma
dc.date.accessioned2025-01-27T20:31:45Z
dc.date.available2025-01-27T20:31:45Z
dc.date.issued2014
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractGastrointestinal Cancers (GICs) are the most important causes of mortality and morbidity in industrialized world. Sister chromatid exchange (SCE), as an index of chromosomal instability, involves cancer. The aim of this study is to determine whether SCE frequency is a heritable factor for GIC or not. The study groups consisted of 15 gastrointestinal carcinoma patients, 13 patient relatives and 15 healthy subjects as the control group. After collection of 2 ml peripheral blood, lymphocytes were cultured for 3 days and sister chromatid exchange (SCE), mitotic index, and replication index were analyzed. SCE was significantly increased (p< 0.01) in patients (16.06 +/- 22.37) and in their relatives (5.23 +/- 2.64) compared with controls (3.51 +/- 1.58). There was no significant difference between patients' relatives and control group in terms of the incidence of SCE frequency. Mitotic index was significantly decreased (p< 0.05, p< 0.01) in patients (5.4 +/- 3.13) compared with healthy relatives (7.15 +/- 2.15) and controls (9.00 +/- 2.26). Replication index was also significantly lower (p< 0.01) in patients (1.39 +/- 0.35) and in their relatives (1.7 +/- 0.21) compared with controls (2.04 +/- 1.13). The results of this study indicate that SCE is a heritable factor for GICs. Increased SCE reflects genomic instability, which is an important factor in carcinogenesis. Although the most putative factors causing genomic instability are epigenetics marks, further studies in combination with epigenetic modifications are needed using more subjects.
dc.identifier.doi10.15197/sabad.1.11.46
dc.identifier.endpage98
dc.identifier.issn1304-3889
dc.identifier.issn1304-3897
dc.identifier.issue2
dc.identifier.scopus2-s2.0-84903529155
dc.identifier.scopusqualityN/A
dc.identifier.startpage94
dc.identifier.urihttps://doi.org/10.15197/sabad.1.11.46
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23261
dc.identifier.volume11
dc.identifier.wosWOS:000421937200007
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherModestum Ltd
dc.relation.ispartofEuropean Journal of General Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectSister chromatid exchange
dc.subjectchromosomal instability
dc.subjectgastrointestinal cancer
dc.titleIncreased Sister Chromatid Exchanges in Patients with Gastrointestinal Cancers and in their First-Degree Relatives
dc.title.alternativeBirinci derecede akrabalarda gastrointestinal kanserli hastalarda artmi{dotless}ş kromatid de?işimler
dc.typeArticle

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