Predictive factors of quality of life in temporal and extratemporal lobe epilepsy: association with affective temperament profiles and psychiatric comorbidities

Başaran, Şehnaz; Taş, Halil İbrahim

Predictive factors of quality of life in temporal and extratemporal lobe epilepsy: association with affective temperament profiles and psychiatric comorbidities

dc.authorid	0000-0001-5849-9068	en_US
dc.authorscopusid	12647668800	en_US
dc.authorwosid	-	en_US
dc.contributor.author	Başaran, Şehnaz
dc.contributor.author	Taş, Halil İbrahim
dc.date.accessioned	2023-08-01T05:46:29Z
dc.date.available	2023-08-01T05:46:29Z
dc.date.issued	2021	en_US
dc.department	Fakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstract	Background: Investigating predictive factors of reduced quality of life (QOL) of patients and their association with focal epilepsy can improve management and treatment strategies. Objective: This study aimed to investigate the relationship between affective temperaments, depression, anxiety, disease characteristics, and QOL and to explore the predictors of QOL in patients with temporal lobe epilepsy (TLE) and extratemporal lobe epilepsy (ETLE). Methods: A total of 50 patients with TLE, 51 patients with ETLE, and 70 controls were enrolled. Affective temperaments were evaluated using the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego-Autoquestionnaire (TEMPS-A). QOL was assessed by the Short-Form Health Survey (SF-36). Beck Depression Inventory and Beck Anxiety Inventory were used to explore depression and anxiety severity, respectively. Results: Compared with the controls, patients with TLE and ETLE had significantly higher scores on all TEMPS-A scales, except on hyperthymic temperament. All the SF-36 subscale scores were lower in the TLE and ETLE groups. Linear regression analysis revealed that depressive symptoms, anxiety, depressive and irritable temperament, and seizure frequency were significant predictors of QOL in TLE. Patients with ETLE with temperamental disturbances, depressive symptoms, and polytherapy had a poorer QOL. Conclusions: Affective temperaments, psychiatric disorders, and clinical factors may predict impaired QOL in patients with TLE and ETLE. Further studies are needed to identify predictors of QOL in various epilepsy subtypes.	en_US
dc.identifier.citation	Başaran, S., & Taş, H.İ. (2021). Predictive factors of quality of life in temporal and extratemporal lobe epilepsy: association with affective temperament profiles and psychiatric comorbidities. Arquivos de Neuro-Psiquiatria, 79(9), 799–807. doi: 10.1590/0004-282x-anp-2020-0437 ‌	en_US
dc.identifier.doi	10.1590/0004-282x-anp-2020-0437
dc.identifier.endpage	807	en_US
dc.identifier.issn	0004-282X
dc.identifier.issn	1678-4227
dc.identifier.issue	9	en_US
dc.identifier.pmid	34669818
dc.identifier.scopus	2-s2.0-85117384408
dc.identifier.startpage	799	en_US
dc.identifier.uri	https://doi.org/10.1590/0004-282x-anp-2020-0437
dc.identifier.uri	https://hdl.handle.net/20.500.12428/4450
dc.identifier.volume	79	en_US
dc.identifier.wos	WOS:000727387000008
dc.identifier.wosquality	Q4
dc.indekslendigikaynak	Web of Science
dc.indekslendigikaynak	Scopus
dc.indekslendigikaynak	PubMed
dc.institutionauthor	Taş, Halil İbrahim
dc.language.iso	en
dc.publisher	Associacao Arquivos de Neuro-Psiquiatria	en_US
dc.relation.ispartof	Arquivos de Neuro-Psiquiatria	en_US
dc.relation.publicationcategory	Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı	en_US
dc.rights	info:eu-repo/semantics/openAccess	en_US
dc.rights	Attribution 3.0 United States	*
dc.rights.uri	http://creativecommons.org/licenses/by/3.0/us/	*
dc.subject	Epilepsy	en_US
dc.subject	Quality of life	en_US
dc.subject	Temperaments	en_US
dc.subject	Temporal lobe	en_US
dc.title	Predictive factors of quality of life in temporal and extratemporal lobe epilepsy: association with affective temperament profiles and psychiatric comorbidities
dc.title.alternative	[Factores predictivos de la calidad de vida en la epilepsia del lóbulo temporal y extratemporal: asociación con perfiles de temperamento afectivo y comorbilidades psiquiátricas]
dc.type	Article