Are Fetuin-A levels beneficial for estimating timing of sepsis occurrence?

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dc.authoridAltinisik, Hatice Betul/0000-0001-9273-0876
dc.contributor.authorAltinisik, Hatice B.
dc.contributor.authorAltinisik, Ugur
dc.contributor.authorUysal, Sema
dc.contributor.authorSacar, Suzan
dc.contributor.authorSimsek, Tuncer
dc.contributor.authorDemiraran, Yavuz
dc.date.accessioned2025-01-27T20:11:55Z
dc.date.available2025-01-27T20:11:55Z
dc.date.issued2018
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjectives: To evaluated Fetuin-A levels of patients admitted in the intensive care unit with a diagnosis of sepsis. Methods: This study was conducted at the Faculty of Medicine, Canakkale Onsekiz Mart University Hospital, Canakkal, Turkey, between February 2015 and October 2015. Forty septic patients were included in the study. Subsequent to clinical suspicion of sepsis, serum levels of C-reactive protein (CRP) and procalcitonin; and white blood cell (WBC) counts were evaluated at 3 time-points: 0 (basal), 24, and 72 hours. Results: The mean Fetuin-A levels at the 3 time-points were 58.5 +/- 29.2 ng/mL, 40.9 +/- 23.6 ng/mL, and 47.8 +/- 25.7 ng/mL, respectively. Fetuin-A levels at 24 hours were significantly lower than the basal level (p<0.05), where as no significant difference was observed between the basal levels and those at 72 hours (p>0.05). Correlation between the temporal changes in Fetuin-A levels and the changes in other inflammatory markers (CRP, procalcitonin and WBC) was examined. Fetuin A was found to have only a negative correlation with serum procalcitonin level (p<0.05). Conclusion: In this study, serum Fetuin-A levels in septic patients decreased significantly in the first 24 hours, followed by an insignificant increase at 72 hours. These findings suggest that monitoring of Fetuin-A levels may help predict the time of occurrence of sepsis and prognosis of sepsis.
dc.description.sponsorshipScientific Research Projects Coordination Unit, Canakkale Onsekiz Mart University, Canakkale, Turkey
dc.description.sponsorshipThis study was supported by the Scientific Research Projects Coordination Unit, Canakkale Onsekiz Mart University, Canakkale, Turkey. We would like to thank Enago for English language editing.
dc.identifier.doi10.15537/smj.2018.7.22418
dc.identifier.endpage684
dc.identifier.issn0379-5284
dc.identifier.issue7
dc.identifier.pmid29968890
dc.identifier.scopus2-s2.0-85049561366
dc.identifier.scopusqualityQ2
dc.identifier.startpage679
dc.identifier.urihttps://doi.org/10.15537/smj.2018.7.22418
dc.identifier.urihttps://hdl.handle.net/20.500.12428/20777
dc.identifier.volume39
dc.identifier.wosWOS:000452509700005
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSaudi Med J
dc.relation.ispartofSaudi Medical Journal
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectAcute-Phase Protein
dc.subjectSerum Fetuin
dc.subjectInflammation
dc.subjectInjury
dc.subjectFetal
dc.subjectRat
dc.titleAre Fetuin-A levels beneficial for estimating timing of sepsis occurrence?
dc.typeArticle

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