Effects of sugammadex on the prevention of postoperative peritoneal adhesions

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dc.authoridHanci, Volkan/0000-0002-2227-194X
dc.contributor.authorSahin, Hasan
dc.contributor.authorToman, Huseyin
dc.contributor.authorKiraz, Hasan Ali
dc.contributor.authorSimsek, Tuncer
dc.contributor.authorErbas, Mesut
dc.contributor.authorOzkul, Faruk
dc.contributor.authorArik, Muhammet Kasim
dc.date.accessioned2025-01-27T20:14:54Z
dc.date.available2025-01-27T20:14:54Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractMany materials and techniques have been used to prevent and repair intra-abdominal adhesions, but an effective solution has not been found. The aim of this study is to research the effect of sugammadex on intra-abdominal adhesions in an experimentally induced intraabdominal adhesion model. Twenty-four female Wistar albino rats were included in the study. The experimental animals were randomly divided into three groups: the sugammadex group (Group SX, n=8), the control group (Group C, n=8), and the shamgroup (Group S, n=8). After starvation for 1 night, the rats were injected with a 50 mg/kg intramuscular dose of ketamine and a 5 mg/kg intramuscular dose of xylazine for anesthesia. The rats in the SX group were given 3 mL sugammadex into the peritoneal cavity, while rats in the control group were given 3 mL 0.9% sodium chloride. In the sham group, the peritoneal cavity was opened, but no chemicals were administered. All rats were sacrificed on the 10th postoperative day. The adhesions were staged as 0, 1, 2, and 3 according to Evans et al.'s model. Our evaluation of macroscopic adhesion intensity found statistically significant differences between the groups. The sugammadex group was observed to have fewer adhesions in a statistically significant manner compared with the control group (p < 0.05). In our experimental intra-abdominal adhesion model in rats, we observed that sugammadex prevented postoperative intra-abdominal adhesions. Copyright (C) 2015, Kaohsiung Medical University. Published by Elsevier Taiwan LLC. All rights reserved.
dc.identifier.doi10.1016/j.kjms.2015.06.007
dc.identifier.endpage467
dc.identifier.issn1607-551X
dc.identifier.issn2410-8650
dc.identifier.issue9
dc.identifier.pmid26362958
dc.identifier.scopus2-s2.0-84941173130
dc.identifier.scopusqualityQ1
dc.identifier.startpage463
dc.identifier.urihttps://doi.org/10.1016/j.kjms.2015.06.007
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21232
dc.identifier.volume31
dc.identifier.wosWOS:000361005400003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofKaohsiung Journal of Medical Sciences
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectExperimental study
dc.subjectPeritoneal adhesion
dc.subjectRats
dc.subjectSugammadex
dc.subjectSurgery
dc.titleEffects of sugammadex on the prevention of postoperative peritoneal adhesions
dc.typeArticle

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