Enzymatic synthesis of 5-amino quinoline oligomers and evaluation of their free radical scavenging activity

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dc.authoridKaya, İsmet / 0000-0002-9813-2962
dc.authoridBilici, Ali / 0000-0002-1377-5580
dc.contributor.authorBilici, Ali
dc.contributor.authorGeçibesler, İbrahim Halil
dc.contributor.authorKaya, İsmet
dc.date.accessioned2025-01-27T20:22:36Z
dc.date.available2025-01-27T20:22:36Z
dc.date.issued2017
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThe compound 5-aminoquinoline (AQ) was treated with horseradish peroxidase (HRP) and H2O2 in a reaction medium containing a dioxane: phosphate buffer mixture (70:30). Products (OAQ) with a degree of polymerization ranging from 4 to 12 were obtained. H-1 NMR, FTIR, UV-vis, SEM, TG-DTA, DSC, XRD analysis, and conductivity measurements were conducted for characterization of OAQ. Compared with a monomer, OAQ showed higher thermal stability. After heating to 1000 degrees C, 46% of the initial weight of the OAQ remained. The antioxidant efficiencies of the monomer and oligomer were evaluated by the typical spectrophotometric method such as the bleaching of 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals. OAQ showed improved DPPH activity compared with the AQ monomer.
dc.description.sponsorshipTUBITAK Grants Commission [TBAG-113Z265]
dc.description.sponsorshipThis work is financially supported by TUBITAK Grants Commission (project No: TBAG-113Z265).
dc.identifier.doi10.1139/cjc-2016-0210
dc.identifier.endpage15
dc.identifier.issn0008-4042
dc.identifier.issn1480-3291
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85008367769
dc.identifier.scopusqualityQ3
dc.identifier.startpage7
dc.identifier.urihttps://doi.org/10.1139/cjc-2016-0210
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21968
dc.identifier.volume95
dc.identifier.wosWOS:000392108700002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherCanadian Science Publishing
dc.relation.ispartofCanadian Journal of Chemistry
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectenzymatic polymerization
dc.subjectHRP
dc.subject5-aminoquinoline
dc.subjectantioxidant activity
dc.subjectDPPH
dc.titleEnzymatic synthesis of 5-amino quinoline oligomers and evaluation of their free radical scavenging activity
dc.typeArticle

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