Hyperbaric oxygen treatment ameliorates gentamicin-induced nephrotoxicity and expression of kidney injury molecule 1 in the rat model

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dc.authoridOztopuz, Ozlem/0000-0002-1373-6311
dc.authoridDemir, Ufuk/0000-0002-0020-1633
dc.authoriduzun, metehan/0000-0003-1406-5473
dc.contributor.authorOztopuz, Ozlem
dc.contributor.authorTurkon, Hakan
dc.contributor.authorSehitoglu, Muserref Hilal
dc.contributor.authorBuyuk, Basak
dc.contributor.authorUzun, Metehan
dc.contributor.authorOvali, Mehmet Akif
dc.contributor.authorDemir, Ufuk
dc.date.accessioned2025-01-27T21:21:36Z
dc.date.available2025-01-27T21:21:36Z
dc.date.issued2019
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIn recent years, hyperbaric oxygen (HBO2) therapy has been considered as an effective method for the treatment of gentamicin (GM)-induced renal toxicity. However, the findings related to the use of HBO2 for GM toxicity are limited and contradictory. The aim of this study is to investigate the protective role of HBO2 on GM-induced nephrotoxicity. For this purpose, Wistar albino rats (n=28) were randomly divided into four equal groups: C, HBO2, GM and GM+HBO2. GM (100 mg/kg, ip) and HBO2 were applied over seven days. On the eighth day blood and kidney tissue samples were harvested. The albumin, creatinine, and urea levels were determined from serum samples. Superoxide dismutase (SOD), glutathion peroxidase (GSH-Px) activities, malondialdehyde (MDA), total antioxidant status (TAS) and total oxidant status (TOS) values were analyzed spectrophotometrically. The relative expression level of TNF-alpha, IL-1 beta and Kim-1 gene were determined by qRT-PCR assays; histopathologic investigation was completed in kidney tissue samples. Serum urea, albumin and creatinine levels significantly increased in the GM group compared to the GM+HBO2 group. For antioxidant parameters the GM+HBO2 group was not statistically different from the C group but was significantly different compared with the GM group. TNF-alpha, IL-1 beta and Kim-1 gene expression levels in the GM group were statistically increased compared to the GM+HBO2 group (p=0.015, p=0.024, p=0.004) respectively. Severe tubular necrosis, epithelial desquamation and mild peritubular hemorrhage were observed in the GM-administrated group, while HBO2 exposure ameliorated these alterations. In conclusion, HBO2 exposure may be defined as a potential method for the prevention of GM-induced renal toxicity.
dc.description.sponsorshipCanakkale Onsekiz Mart UniversityScientific Research Projects [THD-2017-1257]
dc.description.sponsorshipThis study was supported by Canakkale Onsekiz Mart UniversityScientific Research Projects with project number THD-2017-1257.
dc.identifier.endpage133
dc.identifier.issn1066-2936
dc.identifier.issue2
dc.identifier.pmid31051057
dc.identifier.scopus2-s2.0-85065661540
dc.identifier.scopusqualityQ3
dc.identifier.startpage125
dc.identifier.urihttps://hdl.handle.net/20.500.12428/29006
dc.identifier.volume46
dc.identifier.wosWOS:000467369800005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherUndersea & Hyperbaric Medical Soc Inc
dc.relation.ispartofUndersea and Hyperbaric Medicine
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjecthyperbaric oxygen therapy
dc.subjectgentamicin
dc.subjectnephrotoxicity
dc.subjectrat
dc.titleHyperbaric oxygen treatment ameliorates gentamicin-induced nephrotoxicity and expression of kidney injury molecule 1 in the rat model
dc.typeArticle

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