Degradable tannic acid/polyethyleneimine polyplex particles with highly antioxidant and antimicrobial effects

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dc.authoridDemirci, Şahin / 0000-0001-7083-1481
dc.authoridŞahiner, Nurettin / 0000-0003-0120-530X
dc.authoridSağbaş Suner, Selin / 0000-0002-3524-0675
dc.contributor.authorŞahiner, Nurettin
dc.contributor.authorSağbaş, Selin
dc.contributor.authorŞahiner, Mehtap
dc.contributor.authorDemirci, Şahin
dc.date.accessioned2025-01-27T20:11:47Z
dc.date.available2025-01-27T20:11:47Z
dc.date.issued2016
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractTannic acid/Polyethylene imine (TA/PEI) polyplex particles in spherical form were synthesized via the electrostatic interaction between the TA molecules' phenolic groups and PEI positively charged ammonium groups. The size of polyplex particles was observed to be between 500 nm and 5 mu m via SEM images. It was found that the TA/PEI polyplex particles showed thermal durability of 4.8 wt residue in comparison to both components, TA or PEI, at 900 degrees C. Hydrolytic degradation of TA/PEI polyplex particles at different pHs e.g., pH 1.5 similar to stomach conditions, pH 7.4 similar to physiologic conditions, and pH 9 similar to intestinal conditions were investigated by UV-Vis spectroscopy by measuring degraded TA amount at 37.5 degrees C over two days and 65%, 31%, and 52% weight losses were found, respectively. FC, TEAC, and DPPH tests were used to determine the antioxidant properties of TA/PEI polyplex particles. The antimicrobial properties of TA/PEI polyplex particles were determined using micro-dilution and disc diffusion methods against gram-negative Escherichia coli ATCC 8739, Pseudomonas aeruginosa ATCC 10145, gram-positive Staphylococcus aureus ATCC 6538, Bacillus subtilis ATCC 6633 bacteria strains, and Candida albicans ATCC 10231 yeast strain. MIC values of TA/PEI polyplex particles were found to change between 0.025 and 0.1 mg/mL concentration depending on the type of microorganism and indicate that the polyplex particles possess strong antimicrobial activity. (C) 2016 Elsevier Ltd. All rights reserved.
dc.description.sponsorshipScientific and Technological Research Council of Turkey [113Z238]
dc.description.sponsorshipThis work is supported by The Scientific and Technological Research Council of Turkey (113Z238). We are grateful to Assoc. Prof. Dr. Mustafa Turk for cytotoxicity experiments.
dc.identifier.doi10.1016/j.polymdegradstab.2016.08.012
dc.identifier.endpage161
dc.identifier.issn0141-3910
dc.identifier.issn1873-2321
dc.identifier.scopus2-s2.0-84984604214
dc.identifier.scopusqualityQ1
dc.identifier.startpage152
dc.identifier.urihttps://doi.org/10.1016/j.polymdegradstab.2016.08.012
dc.identifier.urihttps://hdl.handle.net/20.500.12428/20726
dc.identifier.volume133
dc.identifier.wosWOS:000386403100017
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier Sci Ltd
dc.relation.ispartofPolymer Degradation and Stability
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectPolyplex particle
dc.subjectTannic acid
dc.subjectPolyethylene imine
dc.subjectAntimicrobial/antioxidant
dc.subjectBiocompatible composites
dc.subjectMicrogel/nanogel polyplex
dc.titleDegradable tannic acid/polyethyleneimine polyplex particles with highly antioxidant and antimicrobial effects
dc.typeArticle

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