Preparation of antioxidant-biodegradable poly(acrylic acid-co-2-hydroxyethyl methacrylate) hydrogel using rutin as a crosslinker: Drug release and anticancer activity

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dc.authoridComert Onder, Ferah/0000-0002-4037-1979
dc.authoridOzay, Hava/0000-0002-4184-7801
dc.contributor.authorOnder, Ferah Comert
dc.contributor.authorOnder, Alper
dc.contributor.authorIlgin, Pinar
dc.contributor.authorOzay, Hava
dc.contributor.authorÖzay, Özgür
dc.date.accessioned2025-01-27T20:17:11Z
dc.date.available2025-01-27T20:17:11Z
dc.date.issued2023
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIt is important to develop drug-release systems that reduce the side effects of chemotherapy drugs, can regulate drug release, and can be designed for a target to keep the quality of life of cancer patients high. In this study, a polyphenol compound rutin was used as a natural crosslinker to prepare poly(acrylic acid-co-2-hydroxyethyl methacrylate)/rutin (RTN hydrogel) as a drug carrier. The swelling behavior, thermal stability, in vitro biode-gradability, and antioxidant activity of this hydrogel were determined. The prepared hydrogel had in vitro biodegradability and antioxidant properties. The maximum doxorubicin (DOX) amount adsorbed by the RTN hydrogel was 32.96 & PLUSMN; 1.83 mg/g. The DOX-loaded RTN hydrogel displayed drug release behavior in normal and cancer cell media. At the same time, the effect of the DOX-loaded hydrogel on triple negative breast cancer (TNBC) cell lines was investigated. Our results show that the RTN hydrogel, prepared using the natural product of rutin as a crosslinker with in vitro biodegradability and antioxidant properties, offers great promise as a high-impact carrier in the drug distribution system.
dc.identifier.doi10.1016/j.reactfunctpolym.2023.105650
dc.identifier.issn1381-5148
dc.identifier.issn1873-166X
dc.identifier.scopus2-s2.0-85162220225
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.reactfunctpolym.2023.105650
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21510
dc.identifier.volume190
dc.identifier.wosWOS:001031596500001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofReactive & Functional Polymers
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectCancer
dc.subjectBiomaterial
dc.subjectHydrogel
dc.subjectBiodegradable
dc.subjectDrug delivery
dc.titlePreparation of antioxidant-biodegradable poly(acrylic acid-co-2-hydroxyethyl methacrylate) hydrogel using rutin as a crosslinker: Drug release and anticancer activity
dc.typeArticle

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