Preparation of antioxidant-biodegradable poly(acrylic acid-co-2-hydroxyethyl methacrylate) hydrogel using rutin as a crosslinker: Drug release and anticancer activity

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dc.authoridCömert Önder, Ferah / 0000-0002-4037-1979
dc.authoridÖnder, Alper / 0000-0002-0775-0053
dc.authoridIlgın, Pınar / 0000-0001-7071-0575
dc.authoridÖzay, Hava / 0000-0002-4184-7801
dc.authoridÖzay, Özgür / 0000-0001-6589-9844
dc.contributor.authorCömert Önder, Ferah
dc.contributor.authorÖnder, Alper
dc.contributor.authorIlgın, Pınar
dc.contributor.authorÖzay, Hava
dc.contributor.authorÖzay, Özgür
dc.date.accessioned2025-01-27T20:17:11Z
dc.date.available2025-01-27T20:17:11Z
dc.date.issued2023
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIt is important to develop drug-release systems that reduce the side effects of chemotherapy drugs, can regulate drug release, and can be designed for a target to keep the quality of life of cancer patients high. In this study, a polyphenol compound rutin was used as a natural crosslinker to prepare poly(acrylic acid-co-2-hydroxyethyl methacrylate)/rutin (RTN hydrogel) as a drug carrier. The swelling behavior, thermal stability, in vitro biodegradability, and antioxidant activity of this hydrogel were determined. The prepared hydrogel had in vitro biodegradability and antioxidant properties. The maximum doxorubicin (DOX) amount adsorbed by the RTN hydrogel was 32.96 ± 1.83 mg/g. The DOX-loaded RTN hydrogel displayed drug release behavior in normal and cancer cell media. At the same time, the effect of the DOX-loaded hydrogel on triple negative breast cancer (TNBC) cell lines was investigated. Our results show that the RTN hydrogel, prepared using the natural product of rutin as a crosslinker with in vitro biodegradability and antioxidant properties, offers great promise as a high-impact carrier in the drug distribution system.
dc.identifier.doi10.1016/j.reactfunctpolym.2023.105650
dc.identifier.issn1381-5148
dc.identifier.issn1873-166X
dc.identifier.scopus2-s2.0-85162220225
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.reactfunctpolym.2023.105650
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21510
dc.identifier.volume190
dc.identifier.wosWOS:001031596500001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofReactive & Functional Polymers
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectCancer
dc.subjectBiomaterial
dc.subjectHydrogel
dc.subjectBiodegradable
dc.subjectDrug delivery
dc.titlePreparation of antioxidant-biodegradable poly(acrylic acid-co-2-hydroxyethyl methacrylate) hydrogel using rutin as a crosslinker: Drug release and anticancer activity
dc.typeArticle

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