Single step natural poly(tannic acid) particle preparation as multitalented biomaterial

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dc.authoridSağbaş Suner, Selin / 0000-0002-3524-0675
dc.authoridŞahiner, Nurettin / 0000-0003-0120-530X
dc.contributor.authorŞahiner, Nurettin
dc.contributor.authorSağbaş, Selin
dc.contributor.authorAktaş, Nahit
dc.date.accessioned2025-01-27T21:01:39Z
dc.date.available2025-01-27T21:01:39Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIn this study, we report the preparation of poly(tannic acid) (p(TA)) particles by crosslinking with glycerol diglycidyl ether (GDE) and trimethylolpropane triglycidyl ether (TMPGDE). The p(TA) particles are negatively charged as obtained by the zeta potential measurements, -27 my.P(TA) particles are found to be an effective antioxidant material as 170 mg L-1 of p(TA) particle demonstrated the antioxidant equivalency of 82.5 +/- 7.2 mg L-1 of gallic acid (GA), used as standard in Folin-Ciocalteau (FC) method. Additionally, TA and p(TA) particles have a strong antimicrobial effect against Escherichia coli ATCC 8739, Staphylococcus aureus ATCC 6538, and Bacillus subtilis ATCC 6633. Furthermore, p(TA) particles were used as drug delivery materials by using model drugs such as TA itself, and GA in the release studies in PBS at pH 7.4 at 37.5 degrees C, and found that p(TA) particles can release 80.8 and 87.4% of the loaded TA and GA, respectively. Interestingly, p(TA) maintained its fluorescent property upon crosslinking of TA units. It is further demonstrated that p(TA) particles are as effective as cisplatin (a cancer drug) against A549 cancerous cells that both showed about 36 and 34% cell viability, respectively whereas linear TA showed 66% cell viability at 37.5 mu g mL(-1) concentration. Above this concentration p(TA) and cisplatin showed almost the same toxicity against A549 cancerous cells. Additionally, p(TA) particles are found to be much more biocompatible against L929 Fibroblast cells, about 84% cell viability in comparison to linear TA with about 53% at 75 mu g mL(-1) concentration. (C) 2015 Elsevier B.V. All rights reserved.
dc.description.sponsorshipScientific and Technological Research Council of Turkey [113Z238]
dc.description.sponsorshipThis work is supported by the Scientific and Technological Research Council of Turkey (113Z238). The authors are grateful to Mustafa Turk from Kirikkale University, for the cell studies.
dc.identifier.doi10.1016/j.msec.2015.01.076
dc.identifier.endpage834
dc.identifier.issn0928-4931
dc.identifier.issn1873-0191
dc.identifier.pmid25687014
dc.identifier.scopus2-s2.0-84922215264
dc.identifier.scopusqualityN/A
dc.identifier.startpage824
dc.identifier.urihttps://doi.org/10.1016/j.msec.2015.01.076
dc.identifier.urihttps://hdl.handle.net/20.500.12428/27137
dc.identifier.volume49
dc.identifier.wosWOS:000350514100095
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Bv
dc.relation.ispartofMaterials Science & Engineering C-Materials For Biological Applications
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectTannic acid
dc.subjectParticles
dc.subjectMicrogel
dc.subjectNanogel antioxidant
dc.subjectAntimicrobial
dc.subjectDrug delivery
dc.titleSingle step natural poly(tannic acid) particle preparation as multitalented biomaterial
dc.typeArticle

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