Use of modifified poly(inulin) micro/nanogels in drug release and blood compatibility tests

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dc.contributor.authorÜlker Çakir, Dilek
dc.contributor.authorSağbaş Suner, Selin
dc.contributor.authorŞahıner, Nurettin
dc.date.accessioned2025-01-27T19:02:27Z
dc.date.available2025-01-27T19:02:27Z
dc.date.issued2019
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: For the use of these obtained micro/nanoparticles in living bodies, physical and chemical properties should be well-known and cells should not cause allergic, toxic or carcinogenic reactions. As a result, after characterization of the prepared p(inulin) particles, their use as drugcarrying system for biomedical applications and blood compatibilities were researched. Material and Methods: Poly(inulin) micro/nanogels were synthesized via reverse micelle microemulsion technique. The prepared p(inulin) particles are determined in spherical morphology with variance dimensions ranging from hundreds of nanometers to tens of micrometers with polydisperse size distribution. The sizes of p(inulin) particles are assessed by optic microscope and scanning electron microscope (SEM). Results:The prepared p(inulin) micro/nanogels are modified with a cationic molecule, 2-bromoethylamine (BEA) and their potential for drug carrier/delivery applications are investigated. It is demonstrated that the p(inulin) micro/nanogels with chemical modification can release Rosmarinic Acid (RA), chosen as a model drug, up to12 h in linear release profile in phosphate saline buffer (PBS) at pH 7.4 and at 37°C. Conclusion: p(inulin) micro/nanogels are shown to be more blood compatible from hemolysis and blood clotting tests, but the modified p(inulin) micro/nanogels are found to have toxic effects depending on the concentration. © 2019 by Türkiye Klinikleri.
dc.identifier.doi10.5336/medsci.2018-62162
dc.identifier.endpage82
dc.identifier.issn1300-0292
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85064338675
dc.identifier.scopusqualityQ4
dc.identifier.startpage75
dc.identifier.trdizinid337982
dc.identifier.urihttps://doi.org/10.5336/medsci.2018-62162
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/337982
dc.identifier.urihttps://hdl.handle.net/20.500.12428/13497
dc.identifier.volume39
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isotr
dc.publisherTurkiye Klinikleri
dc.relation.ispartofTurkiye Klinikleri Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_Scopus_20250125
dc.subjectBlood safety; Drug liberation; Material testing; Nanogel
dc.titleUse of modifified poly(inulin) micro/nanogels in drug release and blood compatibility tests
dc.title.alternativeModifiye poli(inülin) mikro/nanojellerinin ılaç salımında kullanımı ve kan uyumluluklarının tespiti
dc.typeArticle

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