Effects of Local Administration of Boric Acid on Posterolateral Spinal Fusion with Autogenous Bone Grafting in a Rodent Model

Basit Öğe Kaydı
dc.authoridkaymaz, burak/0000-0001-6207-8063
dc.contributor.authorKomurcu, Erkam
dc.contributor.authorOzyalvacli, Gulzade
dc.contributor.authorKaymaz, Burak
dc.contributor.authorGolge, Umut Hatay
dc.contributor.authorGoksel, Ferdi
dc.contributor.authorCevizci, Sibel
dc.contributor.authorAdam, Gurhan
dc.date.accessioned2025-01-27T20:54:16Z
dc.date.available2025-01-27T20:54:16Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractSpinal fusion is among the most frequently applied spinal surgical procedures. The goal of the present study was to evaluate whether the local administration of boric acid (BA) improves spinal fusion in an experimental spinal fusion model in rats. Currently, there is no published data that evaluates the possible positive effects if the local administration of BA on posterolateral spinal fusion. Thirty-two rats were randomly divided into four independent groups: no material was added at the fusion area for group 1; an autogenous morselized corticocancellous bone graft was used for group 2; an autogenous morselized corticocancellous bone graft with boric acid (8.7 mg/kg) for group 3; and only boric acid was placed into the fusion area for group 4. The L4-L6 spinal segments were collected at week 6, and the assessments included radiography, manual palpation, and histomorphometry. A statistically significant difference was determined between the groups with regard to the mean histopathological scores (p=0.002), and a paired comparison was made with the Mann-Whitney U test to detect the group/groups from which the difference originated. It was determined that only the graft+BA practice increased the histopathological score significantly with regard to the control group (p=0.002). Whereas, there was no statistically significant difference between the groups in terms of the manual assessment of fusion and radiographic analysis (respectively p=0.328 and p=0.196). This preliminary study suggests that BA may clearly be useful as a therapeutic agent in spinal fusion. However, further research is required to show the most effective dosage of BA on spinal fusion, and should indicate whether BA effects spinal fusion in the human body.
dc.identifier.doi10.1007/s12011-015-0274-y
dc.identifier.endpage83
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.issue1
dc.identifier.pmid25728510
dc.identifier.scopus2-s2.0-84938952237
dc.identifier.scopusqualityQ1
dc.identifier.startpage77
dc.identifier.urihttps://doi.org/10.1007/s12011-015-0274-y
dc.identifier.urihttps://hdl.handle.net/20.500.12428/26030
dc.identifier.volume167
dc.identifier.wosWOS:000358575600010
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherHumana Press Inc
dc.relation.ispartofBiological Trace Element Research
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectSpinal bone fusion
dc.subjectBoric acid
dc.subjectAutogenous bone graft
dc.subjectRodent model
dc.titleEffects of Local Administration of Boric Acid on Posterolateral Spinal Fusion with Autogenous Bone Grafting in a Rodent Model
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu