Oxidative stress markers in liver in streptozocin-induced diabetic rats: effects of metformin and sitagliptin

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dc.authoridOZTURK, Samil/0000-0002-9435-8139
dc.authoridCAKINA, SUAT/0000-0002-3990-7641
dc.contributor.authorCakina, Suat
dc.contributor.authorOzturk, Samil
dc.date.accessioned2025-01-27T20:54:19Z
dc.date.available2025-01-27T20:54:19Z
dc.date.issued2020
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPurpose: This study aims at investigating the oxidative stress effect of antidiabetic drugs of Metformin (MET) and sitagliptin (STG) in the liver tissue of diabetic rats from streptozotocin (STZ). Materials and Methods: Thirty-five female Wistar rats (3-4 months old, weighing 200 +/- 25 g) were divided into five groups (with seven rats each) and treated as follows: control (Cont), streptozotocin alone (STZ), streptozotocin + metformin (STZ+MET), streptozotocin + sitagliptin (STZ+STG), streptozotocin + metformin + sitagliptin (STZ+MET+STG). Sitagliptin, Metformin, and combined metformin sitagliptin treated subgroups for four weeks. Malondialdehyde (MDA), total antioxidant status (TAS), total oxidant status (TOS) levels, and oxidative stress index (OSI) ratio were measured in rat liver tissue. Besides, cells undergoing apoptotic cell death were determined using the TUNEL technique through histopathological evaluation. Results: MDA, TAS, and OSI of STZ+MET+STG administered group decreased compared to STZ. TOS of STZ+MET+STG administered group decreased compared to STZ. Conclusion: In the experimental T2D model in rats, it shows protective effect when sitagliptin is used with metformin against oxidative damage in liver tissue caused by STZ.
dc.identifier.doi10.17826/cumj.791369
dc.identifier.endpage1741
dc.identifier.issn2602-3032
dc.identifier.issn2602-3040
dc.identifier.issue4
dc.identifier.startpage1733
dc.identifier.trdizinid1115230
dc.identifier.urihttps://doi.org/10.17826/cumj.791369
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1115230
dc.identifier.urihttps://hdl.handle.net/20.500.12428/26041
dc.identifier.volume45
dc.identifier.wosWOS:000609003200054
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherCukurova Univ, Fac Medicine
dc.relation.ispartofCukurova Medical Journal
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectMetformin
dc.subjectsitagliptin
dc.subjectoxidative stress
dc.subjectdiabetes mellitus
dc.titleOxidative stress markers in liver in streptozocin-induced diabetic rats: effects of metformin and sitagliptin
dc.typeArticle

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