Superporous poly(?-Cyclodextrin) cryogels as promising materials for simultaneous delivery of both hydrophilic and hydrophobic drugs

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dc.authoridDemirci, Şahin / 0000-0001-7083-1481
dc.authoridAri, Betül / 0000-0003-3557-3055
dc.authoridŞahiner, Nurettin / 0000-0003-0120-530X
dc.contributor.authorAri, Betül
dc.contributor.authorDemirci, Şahin
dc.contributor.authorAyyala, Ramesh S.
dc.contributor.authorSalih, Bekir
dc.contributor.authorŞahiner, Nurettin
dc.date.accessioned2025-01-27T20:56:12Z
dc.date.available2025-01-27T20:56:12Z
dc.date.issued2022
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractHere, one step, simple preparation of superporous p(beta-cyclodextrin) (p(beta-CD)) cryogels in the presence of various ratios of crosslinker, divinyl sulfone (DVS) e.g., 100, 150, 200% mole with respect to the mole ratio of 6 hydroxyl groups on beta-CD unit under cryogenic conditions were reported for the first time. The swelling properties, and hydrolytic degradation of p(beta-CD) cryogels was directly related to the used crosslinker ratio. It was observed that the p(beta-CD) cryogels showed higher swelling% in DMSO and DMF than in DI water. The prepared p(beta-CD)-1 cryogel that was 100% crosslinked exhibited 14 +/- 3.7%, 34 +/- 4.8%, and 45 +/- 6.2% weight losses within 20 days in pH 5.4, 7.4, and 9.0 buffer solutions, respectively. An acceptable hemolysis index of < 5% and a blood coagulation index, >89% were observed for the p(beta-CD) cryogels at 1 mg/mL concentrations. Additionally, the potential useability of p(beta-CD) cryogels as in vitro drug delivery systems for both hydrophilic vancomycin, and hydrophobic tetracycline as model drugs were individually illustrated at pH 7.4 in PBS. The cumulative drug release from p(beta-CD) cryogels, in sustained release profiles with 76.7 +/- 9.0 mg/g of vancomycin (89.9 +/- 10.5% of the loaded amount) and 146.5 +/- 19.4 mg/g tetracycline g (83.1 +/- 6.3% of the loaded amount) were attained in 6 and 54 h, respectively at pH 7.4 in PBS. Most importantly, p(beta-CD) cryogels exhibited simultaneous loading and releasing the ability for both hydrophilic vancomycin, and hydrophobic tetracycline drugs by concurrently releasing 37.0 +/- 2.7 mg/g (23.4 +/- 1.8% of the loaded amount), and 36.3 +/- 1.3 mg/g (23.6 +/- 0.8% of the loaded amount), respectively at pH 7.4 (PBS) in 10 h.
dc.identifier.doi10.1016/j.eurpolymj.2022.111399
dc.identifier.issn0014-3057
dc.identifier.issn1873-1945
dc.identifier.scopus2-s2.0-85133846722
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.eurpolymj.2022.111399
dc.identifier.urihttps://hdl.handle.net/20.500.12428/26335
dc.identifier.volume176
dc.identifier.wosWOS:000830870300002
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofEuropean Polymer Journal
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectCyclodextrin
dc.subject?-Cyclodextrin cryogel
dc.subjectOligosaccharide cryogel
dc.subjectSimultaneous drug release
dc.subjectHydrophilic
dc.subjecthydrophobic drugs release
dc.titleSuperporous poly(?-Cyclodextrin) cryogels as promising materials for simultaneous delivery of both hydrophilic and hydrophobic drugs
dc.typeArticle

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