Effects of Oriental Sweet Gum Storax on Porcine Wound Healing

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dc.authoridTeke, Zafer/0000-0001-8869-6476
dc.contributor.authorOcsel, Hakan
dc.contributor.authorTeke, Zafer
dc.contributor.authorSacar, Mustafa
dc.contributor.authorKabay, Burhan
dc.contributor.authorDuzcan, S. Ender
dc.contributor.authorKara, Inci Gokalan
dc.date.accessioned2025-01-27T20:45:36Z
dc.date.available2025-01-27T20:45:36Z
dc.date.issued2012
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPurpose: The objective of the present study was to assess the effects of oriental sweet gum (Liquidambar orientalis Mill.) storax on partial-thickness and full-thickness wounds compared to conventional wound dressings in a porcine model. Methods: Six young Yorkshire pigs were used. Sixteen square excisional wounds measuring 3 x 3 cm were performed per animal. The wounds were allocated to one of the four treatment modalities: storax, hydrocolloid dressing, silver sulfadiazine, and control groups. Partial-thickness wounds were created in two pigs, and tissue samples were harvested on days 4 and 8, respectively. Full-thickness wounds were created in four pigs, and tissue samples were taken on days 4, 8, 14, and 21, respectively. Histologically, all wounds were examined for re-epithelialization and granulation tissue formation. Tissue hydroxyproline content and wound contraction areas were measured. Results: In storax-applied group, there was a greater depth of granulation tissue at 4 and 8 days compared to all other groups (p < .0125), and there was a faster re-epithelialization at 21 days compared to both hydrocolloid dressing and control groups in full-thickness wounds (p < .0125). Tissue hydroxyproline content and wound contraction did not differ significantly between the groups. Conclusion: The results of this study indicate that topical application of storax enhanced both re-epithelialization and granulation tissue formation in full-thickness wounds. Further studies are indicated in this important area of wound healing research to evaluate the clinical efficacy of this storax and search for the mechanisms that explain its effects.
dc.identifier.doi10.3109/08941939.2011.639847
dc.identifier.endpage270
dc.identifier.issn0894-1939
dc.identifier.issn1521-0553
dc.identifier.issue4
dc.identifier.pmid22853813
dc.identifier.scopus2-s2.0-84864595252
dc.identifier.scopusqualityQ1
dc.identifier.startpage262
dc.identifier.urihttps://doi.org/10.3109/08941939.2011.639847
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24646
dc.identifier.volume25
dc.identifier.wosWOS:000307012600010
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Inc
dc.relation.ispartofJournal of Investigative Surgery
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectliquidambar orientalis Mill
dc.subjectoriental sweet gum
dc.subjectstorax
dc.subjectstyrax
dc.subjectwound healing
dc.subjectsilver sulfadiazine
dc.subjecthydrocolloid dressing
dc.subjectgranulation tissue
dc.subjectre-epithelialization
dc.titleEffects of Oriental Sweet Gum Storax on Porcine Wound Healing
dc.typeArticle

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