Hyaluronic acid hydrogel particles with tunable charges as potential drug delivery devices

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dc.authoridBütün Şengel, Sultan / 0000-0001-7036-2224
dc.authoridŞahiner, Nurettin / 0000-0003-0120-530X
dc.authoridEkici, Sema / 0000-0001-9940-8388
dc.authoridIlgın, Pınar / 0000-0001-7071-0575
dc.contributor.authorEkici, Sema
dc.contributor.authorIlgın, Pınar
dc.contributor.authorBütün, Sultan
dc.contributor.authorŞahiner, Nurettin
dc.date.accessioned2025-01-27T20:22:48Z
dc.date.available2025-01-27T20:22:48Z
dc.date.issued2011
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractWe report the synthesis of hyaluronic acid (HA) particles with positive and negative charges on their surfaces. HA-based particles were prepared using an aqueous solution of linear HA in a sodium bis(2-ethylhexyl) sulfosuccinate (AOT)-isooctane microemulsion system. The prepared HA particles were post modified, i.e., oxidized to aldehyde (HA-O) by NaIO4 treatment and then these HA-O particles were reacted with cysteamine (CYs) to obtain thiol groups on the surface of the HA particles. The thiolated HA particles (HA-CYs) were further exposed to radical polymerization with an anionic monomer, 2-acrylamido-2-methyl-1-propanesulfonic acid (AMPS), and with a cationic monomer, 3-acrylamidopropyl-trimethylammonium chloride (APTMACl), to generate HA-based ionic hydrogel particles, HA-CYs-AMPS and HA-CYs-APTMACl, respectively. The prepared HA-based anionic and cationic particles illustrated strong pH dependent size variations. We demonstrated that HA-CYs-AMPS and HA-CYs-APTMACl particles can be used as drug delivery vehicles. Trimethoprim (TMP) and naproxen (NN) were used as model drugs in the drug delivery experiments. (C) 2011 Elsevier Ltd. All rights reserved.
dc.description.sponsorshipThe Scientific and Technological Council of Turkey [108T133]; Turkish Academy of Science [2008-TUBA-GEBIP]
dc.description.sponsorshipThis work is supported by The Scientific and Technological Council of Turkey (Grant No.: 108T133). Also N. Sahiner greatly appreciates the financial support from Turkish Academy of Science under 2008-TUBA-GEBIP Program.
dc.identifier.doi10.1016/j.carbpol.2011.01.028
dc.identifier.endpage1313
dc.identifier.issn0144-8617
dc.identifier.issn1879-1344
dc.identifier.issue4
dc.identifier.scopus2-s2.0-79952445216
dc.identifier.scopusqualityQ1
dc.identifier.startpage1306
dc.identifier.urihttps://doi.org/10.1016/j.carbpol.2011.01.028
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22033
dc.identifier.volume84
dc.identifier.wosWOS:000289123300014
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier Sci Ltd
dc.relation.ispartofCarbohydrate Polymers
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectHyaluronic acid hydrogel particles
dc.subjectNatural and synthetic composites
dc.subjectPolyelectrolytes
dc.subjectDrug release
dc.subjectBiocompatible
dc.titleHyaluronic acid hydrogel particles with tunable charges as potential drug delivery devices
dc.typeArticle

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