Moxifloxacin-Impregnated Contact Lenses for Treatment of Keratitis in Rabbit Eyes

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dc.authoridErdoğan, Hakika / 0000-0001-7749-2814
dc.authoridGüngör, Buket / 0000-0002-5802-1635
dc.authoridSağbaş Suner, Selin / 0000-0002-3524-0675
dc.authoridSılan, Coşkun / 0000-0002-8352-6571
dc.authoridŞahiner, Nurettin / 0000-0003-0120-530X
dc.contributor.authorErdoğan, Hakika
dc.contributor.authorGüngör, Buket
dc.contributor.authorSağbaş Suner, Selin
dc.contributor.authorSılan, Coşkun
dc.contributor.authorSaraydın, Serpil U.
dc.contributor.authorSaraydın, Dursun
dc.contributor.authorAyyala, Ramesh S.
dc.contributor.authorŞahiner, Nurettin
dc.date.accessioned2025-05-29T02:58:10Z
dc.date.available2025-05-29T02:58:10Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.descriptionThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the originalwork is properly cited, the use is non-commercial and no modifications or adaptations are made.
dc.description.abstractMoxifloxacin (MOX) was loaded into commercial contact lenses (CLs) via supercritical carbon dioxide (ScCO2) to attain MOX-impregnated CL for keratitis treatment. This study aimed to investigate Pseudomonas keratitis treatment with MOX-impregnated CL compared to the traditional eyedrop administration. MOX impregnation was accomplished employing optimum parameters of 2.5 h drug exposure time, 25 MPa pressure, and 313 K for ScCO2 conditions using ethanol co-solvent rendering sustainable delivery, up to 7 days at effective dosage formulation. The MOX-impregnated CL was found to be safe with no significant toxicity on fibroblast cells after 5 days of contact time. Bacterial viability in vivo keratitis treatment in rabbit eyes was significantly decreased to 10(2) from 10(9) CFU/cornea for MOX-impregnated CL treatment, almost similar to exhaustive conventional 0.5% MOX eye drop treatments. The MOX-impregnated CL treatment revealed no conjunctival hyperemia, edema, or secretion for all eyes in the relevant group, and transparent cornea with no keratitis focus was obtained for two of the eyes (n = 6). The normal histological structure was seen with MOX-impregnated CL treatment on healthy eyes. Moreover, polymorphonuclear cell infiltration observed in keratitis eyes without any treatment was significantly decreased to a few polymorphonuclear cells in the groups treated with MOX eyedrops and MOX-impregnated CL.
dc.description.sponsorshipTrkiye Bilimsel ve Teknolojik Arascedil;timath;rma Kurumu [122M641]; TUBITAK
dc.description.sponsorshipThis work is supported by TUBITAK (122M641) which is greatly appreciated.
dc.identifier.doi10.1002/pat.70134
dc.identifier.issn1042-7147
dc.identifier.issn1099-1581
dc.identifier.issue3
dc.identifier.scopus2-s2.0-86000065968
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1002/pat.70134
dc.identifier.urihttps://hdl.handle.net/20.500.12428/30295
dc.identifier.volume36
dc.identifier.wosWOS:001436970600001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofPolymers For Advanced Technologies
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250529
dc.subjectkeratitis treatment
dc.subjectmoxifloxacin-impregnated contact lens
dc.subjectPseudomonas keratitis
dc.subjectsupercritical carbon dioxide (ScCO2)
dc.subjectsustainable drug delivery
dc.titleMoxifloxacin-Impregnated Contact Lenses for Treatment of Keratitis in Rabbit Eyes
dc.typeArticle

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