A neutral arene ruthenium(II) complex with a sulfonated N,O-chelating ligand: Synthesis, characterization, in vitro cytotoxicity and antibacterial activity

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dc.authoriddayan, osman/0000-0002-0764-1965
dc.authoridOzdemir, Namik/0000-0003-3371-9874
dc.authoridozdemir, Fethi Ahmet/0000-0001-7215-9692
dc.authoridAYKUTOGLU, GURKAN/0000-0002-5225-9845
dc.contributor.authorSelvi, Gizem
dc.contributor.authorOzdemir, Fethi Ahmet
dc.contributor.authorAykutoglu, Gurkan
dc.contributor.authorOzdemir, Namik
dc.contributor.authorSerbetci, Zafer
dc.contributor.authorCetinkaya, Bekir
dc.contributor.authorDayan, Osman
dc.date.accessioned2025-01-27T21:05:45Z
dc.date.available2025-01-27T21:05:45Z
dc.date.issued2020
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIn this work, a new N,O-type ligand (L1H) containing a sulfonate ester group and its heteroleptic Ru(II) complex (C1) have been prepared and structurally characterized by various techniques, such as UV-vis, ESI-MS, NMR and IR. The spectroscopic results (IR, UV-vis and NMR) were compared with the results of density functional theory (DFT) calculations. The solid-state structures of L1H and C1 were crystallographically verified. Moreover, the in vitro cytotoxicity and antibacterial properties of 1, L1H and Cl have been screened. All the compounds exhibited good cytotoxicity towards human neuroblastoma cancer cells and antibacterial effects towards 16 bacterial strains, both gram positive and negative. The results revealed that the Ru(II) complex exhibits higher biological activities than the starting materials 1 and L1H. (C) 2019 Elsevier Ltd. All rights reserved.
dc.description.sponsorshipCanakkale Onsekiz Mart University [FYL-2019-2883]; Ondokuz Maps University [PYO.FEN.1906.19.001]; Turkish Academy of Science (TUBA)
dc.description.sponsorshipThis study was supported by Canakkale Onsekiz Mart University (Project No: FYL-2019-2883) and Ondokuz Maps University (Project No: PYO.FEN.1906.19.001). We also thank Amasya University, Turkey, for the use of GaussView 5.0 and the Gaussian 09 program package. Bekir Cetinkaya thanks the Turkish Academy of Science (TUBA) for support.
dc.identifier.doi10.1016/j.poly.2019.114300
dc.identifier.issn0277-5387
dc.identifier.scopus2-s2.0-85076696612
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.poly.2019.114300
dc.identifier.urihttps://hdl.handle.net/20.500.12428/27780
dc.identifier.volume176
dc.identifier.wosWOS:000517658300022
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofPolyhedron
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectHeteroleptic Ru(II) complex
dc.subjectSulfonated N,O-ligand
dc.subjectCytotoxicity
dc.subjectAntibacterial activity
dc.titleA neutral arene ruthenium(II) complex with a sulfonated N,O-chelating ligand: Synthesis, characterization, in vitro cytotoxicity and antibacterial activity
dc.typeArticle

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