Adjunctive Hyperbaric Oxygen Therapy or Alone Antibiotherapy? Methicillin Resistant Staphylococcus aureus Mediastinitis in a Rat Model

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dc.contributor.authorKurt, Tolga
dc.contributor.authorVural, Ahmet
dc.contributor.authorTemiz, Ahmet
dc.contributor.authorOzbudak, Ersan
dc.contributor.authorYener, Ali Umit
dc.contributor.authorSacar, Suzan
dc.contributor.authorSacar, Mustafa
dc.date.accessioned2025-01-27T20:59:36Z
dc.date.available2025-01-27T20:59:36Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: In the post-sternotomy mediastinitis patients, Staphylococcus aureus is the pathogenic microorganism encountered most often. In our study, we aimed to determine the efficacy of antibiotic treatment with vancomycin and tigecycline, alone or in combination with hyperbaric oxygen treatment, on bacterial elimination in experimental S. aureus mediastinitis. Methods: Forty-nine adult female Wistar rats were used. They were randomly divided into seven groups, as follows: non-contaminated, contaminated control, vancomycin, tigecycline, hyperbaric oxygen, hyperbaric oxygen + vancomycin and hyperbaric oxygen + tigecycline. The vancomycin rat group received 10 mg/kg/day of vancomycin twice a day through intramuscular injection. The tigecycline group rats received 7 mg/kg/day of tigecycline twice a day through intraperitoneal injection. The hyperbaric oxygen group underwent 90 min sessions of 100% oxygen at 2.5 atm pressure. Treatment continued for 7 days. Twelve hours after the end of treatment, tissue samples were obtained from the upper part of the sternum for bacterial count assessment. Results: When the quantitative bacterial counts of the untreated contaminated group were compared with those of the treated groups, a significant decrease was observed. However, comparing the antibiotic groups with the same antibiotic combined with hyperbaric oxygen, there was a significant reduction in microorganisms identified (P<0.05). Comparing hyperbaric oxygen used alone with the vancomycin and tigecycline groups, it was seen that the effect was not significant (P<0.05). Conclusion: We believe that the combination of hyperbaric oxygen with antibiotics had a significant effect on mediastinitis resulting from methicillin-resistant Staphylococcus aureus. Methicillin-resistant Staphylococcus aureus mediastinitis can be treated without requiring a multidrug combination, thereby reducing the medication dose and concomitantly decreasing the side effects.
dc.identifier.doi10.5935/1678-9741.20150055
dc.identifier.endpage543
dc.identifier.issn0102-7638
dc.identifier.issn1678-9741
dc.identifier.issue5
dc.identifier.pmid26735600
dc.identifier.scopus2-s2.0-84954455528
dc.identifier.scopusqualityQ2
dc.identifier.startpage538
dc.identifier.urihttps://doi.org/10.5935/1678-9741.20150055
dc.identifier.urihttps://hdl.handle.net/20.500.12428/26738
dc.identifier.volume30
dc.identifier.wosWOS:000366733800006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSoc Brasil Cirurgia Cardiovasc
dc.relation.ispartofRevista Brasileira De Cirurgia Cardiovascular
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectMediastinitis
dc.subjectHyperbaric Oxygenation
dc.subjectVancomycin
dc.titleAdjunctive Hyperbaric Oxygen Therapy or Alone Antibiotherapy? Methicillin Resistant Staphylococcus aureus Mediastinitis in a Rat Model
dc.typeArticle

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