Chronic obstructive pulmonary disease phenotypes in Turkey: the COPET study-a national, multicenter cross-sectional observational study

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dc.authoridMETE, BURAK/0000-0002-0780-6176
dc.authoridOzturk, Ayperi/0000-0003-0692-4784
dc.authoridtural onur, seda/0000-0002-0657-0392
dc.contributor.authorYazar, Esra Ertan
dc.contributor.authorYigitbas, Burcu Arpinar
dc.contributor.authorOzturk, Can
dc.contributor.authorCalikoglu, Mukadder
dc.contributor.authorGulbas, Gazi
dc.contributor.authorTuran, Muzaffer Onur
dc.contributor.authorSahin, Hulya
dc.date.accessioned2025-01-27T20:20:51Z
dc.date.available2025-01-27T20:20:51Z
dc.date.issued2022
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground/aim: While mortality rates decrease in many chronic diseases, it continues to increase in COPD. This situation has led to the need to develop new approaches such as phenotypes in the management of COPD. We aimed to investigate the distribution, characteristics and treatment preference of COPD phenotypes in Turkey. Materials and methods: The study was designed as a national, multicenter, observational and cross-sectional. A total of 1141 stable COPD patients were included in the analysis. Results: The phenotype distribution was as follows: 55.7% nonexacerbators (NON-AE), 25.6% frequent exacerbators without chronic bronchitis (AE NON-CB), 13.9% frequent exacerbators with chronic bronchitis (AE-CB), and 4.8% with asthma and COPD overlap (ACO). The FEV 1 values were significantly higher in the ACO and NON- AE than in the AE-CB and AE NON-CB (p < 0.001). The symptom scores, ADO (age, dyspnoea and FEV 1) index and the rates of exacerbations were significantly higher in the AE-CB and AE NON-CB phenotypes than in the ACO and NON-AE phenotypes (p < 0.001). Treatment preference in patients with COPD was statistically different among the phenotypes (p < 0.001). Subgroup analysis was performed in terms of emphysema, chronic bronchitis and ACO phenotypes of 1107 patients who had thoracic computed tomography. A total of 202 patients had more than one phenotypic trait, and 149 patients showed no features of a specific phenotype. Conclusion: Most of the phenotype models have tried to classify the patient into a certain phenotype so far. However, we observed that some of the patients with COPD had two or more phenotypes together. Therefore, rather than determining which phenotype the patients are classified in, searching for the phenotypic traits of each patient may enable more effective and individualized treatment.
dc.identifier.doi10.55730/1300-0144.5416
dc.identifier.endpage1138
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue4
dc.identifier.pmid36326395
dc.identifier.startpage1130
dc.identifier.trdizinid1144741
dc.identifier.urihttps://doi.org/10.55730/1300-0144.5416
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1144741
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21830
dc.identifier.volume52
dc.identifier.wosWOS:000881194200031
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTubitak Scientific & Technological Research Council Turkey
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectACO
dc.subjectchronic bronchitis
dc.subjectCOPD
dc.subjectemphysema
dc.subjectphenotype
dc.titleChronic obstructive pulmonary disease phenotypes in Turkey: the COPET study-a national, multicenter cross-sectional observational study
dc.typeArticle

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