Effects of Tannic Acid on the Ischemic Brain Tissue of Rats

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dc.authoridguven, mustafa/0000-0001-8643-9775
dc.authoridSılan, Coşkun/0000-0002-8352-6571
dc.authoridAras, Adem Bozkurt/0000-0002-0140-5224
dc.contributor.authorSen, Halil Murat
dc.contributor.authorOzkan, Adile
dc.contributor.authorGuven, Mustafa
dc.contributor.authorAkman, Tarik
dc.contributor.authorAras, Adem Bozkurt
dc.contributor.authorSehitoglu, Ibrahim
dc.contributor.authorAlacam, Hasan
dc.date.accessioned2025-01-27T20:45:37Z
dc.date.available2025-01-27T20:45:37Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractMany studies of brain ischemia have shown the role played by massive ischemia-induced production of reactive oxygen species, the main mechanism of neuronal death. However, currently, there is no treatment choice to prevent cell death triggered by reactive oxygen species. In our study, we researched the effects of tannic acid, an antioxidant, on the ischemic tissue of rats with induced middle cerebral artery occlusion. The animals were divided into three groups of eight animals. The sham group were only administered 10 % ethanol intraperitoneally, the second group had middle cerebral artery occlusion induced and were given 10 % ethanol intraperitoneally, while the third group had middle cerebral artery occlusion with 10 mg/kg dose tannic acid dissolved in 10 % ethanol administered within half an hour intraperitoneally. The rats were sacrificed 24 h later, and brain tissue was examined biochemically and histopathologically. Biochemical evaluation of brain tissue found that comparing the ischemic group with no treatment with the tannic acid-treated ischemia group; the superoxide dismutase (SOD) levels were higher, malondialdehyde (MDA) levels were lower, and nuclear respiratory factor-1 (NRF-1) was higher in the tannic acid-treated group. Histopathological examination showed that the histopathological results of the tannic acid group were better than the group not given tannic acid. Biochemical and histopathological results showed that tannic acid administration had an antioxidant effect on the negative effects of ischemia in brain tissue.
dc.description.sponsorshipCanakkale Onsekiz Mart University Experimental Research Center (COMUDAM)
dc.description.sponsorshipThis study was supported by the Canakkale Onsekiz Mart University Experimental Research Center (COMUDAM).
dc.identifier.doi10.1007/s10753-015-0138-9
dc.identifier.endpage1630
dc.identifier.issn0360-3997
dc.identifier.issn1573-2576
dc.identifier.issue4
dc.identifier.pmid25697604
dc.identifier.scopus2-s2.0-84937253513
dc.identifier.scopusqualityQ1
dc.identifier.startpage1624
dc.identifier.urihttps://doi.org/10.1007/s10753-015-0138-9
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24655
dc.identifier.volume38
dc.identifier.wosWOS:000357666000028
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer/Plenum Publishers
dc.relation.ispartofInflammation
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectantioxidants
dc.subjectcerebrum
dc.subjectischemia
dc.subjecttannic acid
dc.titleEffects of Tannic Acid on the Ischemic Brain Tissue of Rats
dc.typeArticle

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