Self-assembled silibinin-containing phosphazene/cystamine hybrid nanospheres as biodagradable dual-drug carriers with improved anticancer activity on a breast cancer cell line

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dc.authoridComert Onder, Ferah/0000-0002-4037-1979
dc.authoridÖzay, Özgür/0000-0001-6589-9844
dc.authoridOnder, Alper/0000-0002-0775-0053
dc.contributor.authorOzsoy, Fatma
dc.contributor.authorOnder, Ferah Comert
dc.contributor.authorIlgin, Pinar
dc.contributor.authorOzay, Hava
dc.contributor.authorOnder, Alper
dc.contributor.authorÖzay, Özgür
dc.date.accessioned2025-01-27T20:24:35Z
dc.date.available2025-01-27T20:24:35Z
dc.date.issued2023
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIn this study, pH and redox sensitive biodegradable PPZs@Silibinin polymeric nanospheres were synthesized by the polymerization reaction of Hexachlorocyclotriphosphazene (HCCP), Cystamine dihydrochloride (CA) and the anticancer drug Silibinin as monomers. Later designed as a therapeutic system, this nano drug-carrier was also loaded with Doxorubicin (Dox), a type of cancer drug. As a result, a drug self-delivery system (DSDS) was developed, which had the property of biodegradation in tumor tissues thanks to the redox active disulfide bonds in its structure from pH-sensitive nanospheres containing two anticancer drugs. Biodegradation-associated in vitro release of cancer drug (Dox) from the Dox loaded PPZs@Silibinin nano drug-carrier was performed in the presence of glutathione (GSH) at pH 6.5 and pH 7.4. While 93.06% Dox release was observed in pH 6.5 medium containing 10 mM GSH in 24 h, this value was 56.60% in pH 7.4 + 10 mM GSH medium. In addition, clonogenic analysis and cytotoxicity studies were performed on the MDA-MB-231 cell line to determine the anticancer properties of PPZs@Silibinin loaded with Dox. It was determined that PPZs@Silibinin@Dox nanospheres containing 20.5 nM Dox for 0.75 mu L are highly effective in MDA-MB-231 cells than free Dox.
dc.description.sponsorshipCanakkale Onsekiz Mart University, Scientific Research Coordination Unit [FBA-2022-3855]
dc.description.sponsorshipThis work was supported by Canakkale Onsekiz Mart University, Scientific Research Coordination Unit (Project number: FBA-2022-3855) . The authors would like to thank Prof. Dr. Zuhal Hamurcu, ( Ph.D.) for providing cell line.
dc.identifier.doi10.1016/j.mtcomm.2023.107116
dc.identifier.issn2352-4928
dc.identifier.scopus2-s2.0-85171452312
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.mtcomm.2023.107116
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22286
dc.identifier.volume37
dc.identifier.wosWOS:001081804000001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofMaterials Today Communications
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectBreast cancer
dc.subjectNanospheres
dc.subjectBiodegradable
dc.subjectDoxorubicin
dc.subjectDrug-carrier
dc.titleSelf-assembled silibinin-containing phosphazene/cystamine hybrid nanospheres as biodagradable dual-drug carriers with improved anticancer activity on a breast cancer cell line
dc.typeArticle

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