Traumatic brain injury: a review of pathophysiology and therapeutic potential of polyphenols

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dc.authorid0000-0003-0170-6825
dc.contributor.authorShahbaz, Sanaz Keshavarz
dc.contributor.authorFathollazadeh, Pourya
dc.contributor.authorZare, Isareza
dc.contributor.authorSathyapalan, Thozhukat
dc.contributor.authorSadeghi, Mahvash
dc.contributor.authorDehnavi, Sajad
dc.contributor.authorKarav, Sercan
dc.date.accessioned2026-02-03T12:02:25Z
dc.date.available2026-02-03T12:02:25Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjectivesTraumatic brain injury (TBI) is severe and may become debilitating for sufferers as a result of damage to the brain. Defining features include primary trauma, axonal damage, as well as both diffuse and focal lesions. One of the many complex biological responses to TBI are neuroinflammation and oxidative stress which are among the most important.MethodsIn this study, we assess the efficacy of polyphenols compounds on managing TBI, given that they are anti-inflammatory and antioxidant. We focus on recent literature that studies the impact of polyphenols on microglial activation as well as balancing the body's inflammatory and oxidative responses.ResultsEvidence demonstrates the ability of polyphenols to lessen the impact of neuroinflammation, oxidative stress, and augmentation of the brain's protective mechanisms and antioxidants. This may help prevent the worsening of brain tissue damage that occurs post TBI. Based on these, there is increasing attention on polyphenols as potential treatment alternatives due to their non-invasive nature.DiscussionWe enumerated some polyphenols with important therapeutic impacts in TBI such as Curcumin and Resveratrol, Quercetin, Gallic acid, Ferulic acid, Luteolin, and Caffeic acid. Their ability to target multiple damaging processes makes them strong candidates.
dc.identifier.doi10.1080/1028415X.2025.2508773
dc.identifier.endpage1288
dc.identifier.issn1028-415X
dc.identifier.issn1476-8305
dc.identifier.issue10
dc.identifier.pmid40440244
dc.identifier.scopus2-s2.0-105007026719
dc.identifier.scopusqualityQ1
dc.identifier.startpage1255
dc.identifier.urihttps://doi.org/10.1080/1028415X.2025.2508773
dc.identifier.urihttps://hdl.handle.net/20.500.12428/34752
dc.identifier.volume28
dc.identifier.wosWOS:001499669400001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofNutritional Neuroscience
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20260130
dc.subjectTraumatic brain injury
dc.subjectcurcumin
dc.subjectresveratrol
dc.subjectquercetin
dc.subjectgallic acid
dc.subjectferulic acid
dc.subjectluteolin
dc.subjectcaffeic acid
dc.titleTraumatic brain injury: a review of pathophysiology and therapeutic potential of polyphenols
dc.typeReview

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