Synthesis, characterization and catalytic, cytotoxic and antimicrobial activities of two novel cyclotriphosphazene-based multisite ligands and their Ru(II) complexes

Basit Öğe Kaydı
dc.authoridUYAR, Zafer/0000-0002-6310-8823
dc.authoridkoyuncu, ismail/0000-0002-9469-4757
dc.contributor.authorCirali, Digdem Erdener
dc.contributor.authorUyar, Zafer
dc.contributor.authorKoyuncu, Ismail
dc.contributor.authorHacioglu, Nurcihan
dc.date.accessioned2025-01-27T20:14:41Z
dc.date.available2025-01-27T20:14:41Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractTwo novel cyclotriphosphazene ligands (2 and 3) bearing 3-oxypyridine groups and their corresponding Ru(II) complexes (4 and 5) were synthesized and their structures were characterized using Fourier transform infrared, H-1 NMR and P-31 NMR spectroscopic data and elemental analysis. The Ru(II) complexes were used as catalysts for catalytic transfer hydrogenation of p-substituted acetophenone derivatives in the presence of KOH. Additionally, the cytotoxic activities of compounds 2, 3, 4, 5 were evaluated against PC3 (human prostate cancer), DLD-1 (human colorectal cancer), HeLa (human cervical cancer) and PNT1A (normal human prostate) cell lines. Finally the antimicrobial activities of compounds 2, 3, 4, 5 were evaluated against a panel of Gram-positive and Gram-negative bacteria and yeast cultures. The complexes showed efficient catalytic activity towards transfer hydrogenation of acetophenone derivatives, especially those bearing electron-withdrawing substituents on the para-position of the aryl ring. The compounds were found to have moderate to high cytotoxic and antimicrobial activities, and Ru(II) complexation enhanced both cytotoxic and antimicrobial activities in comparison with the parent compounds. Copyright (c) 2015 John Wiley & Sons, Ltd.
dc.description.sponsorshipScientific and Technical Research Council of Turkey (TUBITAK) [112T584]
dc.description.sponsorshipWe are grateful to the Scientific and Technical Research Council of Turkey (TUBITAK) for the financial support of this work, grant number 112T584.
dc.identifier.doi10.1002/aoc.3328
dc.identifier.endpage542
dc.identifier.issn0268-2605
dc.identifier.issn1099-0739
dc.identifier.issue8
dc.identifier.scopus2-s2.0-84937967655
dc.identifier.scopusqualityQ1
dc.identifier.startpage536
dc.identifier.urihttps://doi.org/10.1002/aoc.3328
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21171
dc.identifier.volume29
dc.identifier.wosWOS:000358533300008
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofApplied Organometallic Chemistry
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectcyclotriphosphazene
dc.subjectRu(II) complex
dc.subjecttransfer hydrogenation
dc.subjectcytotoxicity
dc.subjectantimicrobial activity
dc.titleSynthesis, characterization and catalytic, cytotoxic and antimicrobial activities of two novel cyclotriphosphazene-based multisite ligands and their Ru(II) complexes
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu