An immunohistochemistry and histopathological study of ankaferd blood stopper in a rat model of cervical inflammation

Basit Öğe Kaydı
dc.contributor.authorBeyazit, Fatma
dc.contributor.authorBuyuk, Basak
dc.date.accessioned2025-01-27T20:35:07Z
dc.date.available2025-01-27T20:35:07Z
dc.date.issued2019
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractOBJECTIVE: Ankaferd Blood Stopper (ABS) is a medicinal plant extract used topically as a hemostatic, anti-inflammatory, and anti-oxidant agent. Its cytoprotective effect mainly depends on its pleiotropic properties by modulating inflammatory mediators such as IL-1 beta, IL-6, and TNF-alpha. This study aims to test the possible therapeutic effect of ABS in the treatment of erosive and inflammatory conditions occurring in the uterine cervix. METHODS: Twenty-four female Wistar Albino rats were used in the present study. Trichloracetic acid was applied intravaginally to establish an experimental rat model of cervicitis. The rats were randomly divided into three groups: group I (injury), group II (injury+isotoinc saline), and group III (injury+ABS). After 3 estrous cycles of ABS and isotonic saline treatment, the amount of inflammation, vascular congestion and erosion were evaluated in the cervical tissues by using a modified semi-quantitative scale of 0-3. Immunohistochemical staining with monoclonal antibodies against IL-1 beta was also performed. RESULTS: Compared with group I and II, the ABS group showed the least inflammatory cell infiltration, vascular congestion and cervical erosion, compared with the ABS group prominent IL-1 beta staining observed in group I and group II. CONCLUSION: Our data suggest that ABS is a highly effective alternative to induce normal cervical epithelium and can be used safely in the treatment of cervical inflammation with or without cervical erosion.
dc.identifier.doi10.1590/1806-9282.65.2.183
dc.identifier.endpage190
dc.identifier.issn1806-9282
dc.identifier.issue2
dc.identifier.pmid30892442
dc.identifier.scopus2-s2.0-85063281196
dc.identifier.scopusqualityQ2
dc.identifier.startpage183
dc.identifier.urihttps://doi.org/10.1590/1806-9282.65.2.183
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23574
dc.identifier.volume65
dc.identifier.wosWOS:000461474100016
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAssoc Medica Brasileira
dc.relation.ispartofRevista Da Associacao Medica Brasileira
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectUterine cervicitis
dc.subjectUterine cervical diseases
dc.subjectInflammation
dc.subjectInterleukin-1beta
dc.subjectPlant extracts/*pharmacology
dc.titleAn immunohistochemistry and histopathological study of ankaferd blood stopper in a rat model of cervical inflammation
dc.typeArticle

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