Titanium platelet-rich fibrin (T-PRF) as high-capacity doxycycline delivery system

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dc.authoridErcan, Esra / 0000-0002-8696-4198
dc.authoridSağbaş Suner, Selin / 0000-0002-3524-0675
dc.authoridSılan, Coşkun / 0000-0002-8352-6571
dc.authoridYılmaz, Selehattin / 0000-0003-4607-3523
dc.authoridSıddıkoğlu, Duygu / 0000-0002-5093-7948
dc.authoridŞahiner, Nurettin / 0000-0003-0120-530X
dc.authoridTunalı, Mustafa / 0000-0002-1251-3431
dc.contributor.authorErcan, Esra
dc.contributor.authorSağbaş Suner, Selin
dc.contributor.authorSılan, Coşkun
dc.contributor.authorYılmaz, Selehattin
dc.contributor.authorSıddıkoğlu, Duygu
dc.contributor.authorŞahiner, Nurettin
dc.contributor.authorTunalı, Mustafa
dc.date.accessioned2025-01-27T20:54:34Z
dc.date.available2025-01-27T20:54:34Z
dc.date.issued2022
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjectives Titanium platelet-rich fibrin (T-PRF), a second-generation autogenous blood concentrate with tough and thick fibrin meshwork activated by a titanium tube, was used as a drug carrier for doxycycline (Doxy) by injection. The objective of this study is to evaluate the loading capacity of T-PRF, release kinetics of doxycycline-loaded T-PRF, and its antibacterial effects against S. aureus and P. aeruginosa. Materials and methods The T-PRF and collagen were loaded with Doxy as T-PRF/Doxy and Collagen/Doxy, and their release and antibacterial activities against S. aureus and P. aeruginosa were investigated. Chemical characterization and morphological analysis were performed. Results In comparison with collagen, approximately sevenfold more Doxy, 281 mg/g, was loaded into T-PRF. It was found that 25% of the loaded Doxy was released from T-PRF compared to only 12% from collagen within 72 h. The largest inhibition zone diameter (IZD) was observed for T-PRF/Dox with 32 +/- 6 mm and 37 +/- 5 mm for P. aereginosa and S. aureus, respectively. However, only 10 +/- 5 mm and 10 +/- 6 mm IZD were observed for bare T-PRF, and no inhibition zone was observed for the Collagen/Doxy group. A dense fibrin structure was visualized on SEM images of the T-PRF/Doxy group compared to the T-PRF group. Conclusions T-PRF has higher Doxy loading capacity and long-acting antibacterial effects compared to collagen. T-PRF was shown to have potential autogenous long-term drug-carrying capability for doxycycline. Also, the potential fibrinophilic properties of Doxy were observed to strengthen the structure of T-PRF.
dc.description.sponsorshipCOMUBAP [TSA-2021-3494]
dc.description.sponsorshipThe authors thank Canakkale Onsekiz Mart University Scientific Research Council. This Project was supported by COMUBAP with Project number TSA-2021-3494.
dc.identifier.doi10.1007/s00784-022-04510-0
dc.identifier.endpage5438
dc.identifier.issn1432-6981
dc.identifier.issn1436-3771
dc.identifier.issue8
dc.identifier.pmid35501503
dc.identifier.scopus2-s2.0-85129283529
dc.identifier.scopusqualityQ1
dc.identifier.startpage5429
dc.identifier.urihttps://doi.org/10.1007/s00784-022-04510-0
dc.identifier.urihttps://hdl.handle.net/20.500.12428/26105
dc.identifier.volume26
dc.identifier.wosWOS:000789759400001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer Heidelberg
dc.relation.ispartofClinical Oral Investigations
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectTitanium platelet-rich fibrin
dc.subjectT-PRF
dc.subjectDoxycycline
dc.subjectDrug delivery
dc.subjectS
dc.subjectaureus
dc.subjectP
dc.subjectaeruginosa
dc.titleTitanium platelet-rich fibrin (T-PRF) as high-capacity doxycycline delivery system
dc.typeArticle

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