Role of bovine colostrum against various diseases

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dc.authoridFerreira da Rocha, Joao Miguel/0000-0002-0936-2003
dc.authoridKARAV, SERCAN/0000-0003-4056-1673
dc.authoridOZOGUL, Fatih/0000-0002-0655-0105
dc.contributor.authorYalcintas, Yalcin Mert
dc.contributor.authorDuman, Hatice
dc.contributor.authorRocha, Joao Miguel
dc.contributor.authorBartkiene, Elena
dc.contributor.authorKarav, Sercan
dc.contributor.authorOzogul, Fatih
dc.date.accessioned2025-01-27T20:29:03Z
dc.date.available2025-01-27T20:29:03Z
dc.date.issued2024
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractColostrum refers to the initial milk that mammals generate following childbirth, and it possesses rich nutritional value. Due to its bioactive components (such as lactoferrin, lactoperoxidase, and immunoglobulins), colostrum actively contributes to various positive immune functions and specific cellular processes within the consumer's body. In clinical applications, research has shown that the immunoglobulins found in colostrum support the immune system, playing key roles in cell growth and development. Growth factors also contribute to various processes, including wound healing and metabolic functions. Lactoferrin and lactoperoxidase support the body's immunity, while another bioactive component, functional oligosaccharides, selectively promote growth in the microbiome. Additionally, nucleotide monophosphates play crucial roles in numerous vital physiological functions, including the synthesis of proteins, lipids, and carbohydrates. The supplementation of colostrum has shown promising results in combating various diseases caused by different pathogens, such as gastrointestinal infections, diarrhea, gut-barrier diseases, and inflammatory bowel disease. Based on reports of these clinical applications, the effects of colostrum against various diseases have been observed. Further research may reveal different therapeutic effects of colostrum on different diseases. By exploring the clinical applications of colostrum supplementation and the mechanisms of action of its bioactive components against specific diseases, this review highlights the potential of colostrum as a therapeutic agent and provides insights into its multifaceted effects.
dc.description.sponsorshipFCT/MCTES (PIDDAC): LEPABE [UIDB/00511/2020, UIDP/00511/2020]; FCT/MCTES (PIDDAC): ALiCE [LA/P/0045/2020]; FCT [UIDB/50016/2020]
dc.description.sponsorshipThe work of the author J.M.R. was supported by national funds through FCT/MCTES (PIDDAC): LEPABE, UIDB/00511/2020 (DOI: 10.54499/UIDB/00511/2020) and UIDP/00511/2020 (DOI: 10.54499/UIDP/00511/2020) and ALiCE, LA/P/0045/2020 (DOI: 10.54499/LA/P/0045/2020). The author J.M.R acknowledges the Universidade Catolica Portuguesa, CBQF - Centro de Biotecnologia e Quimica Fina - Laboratorio Associado, Escola Superior de Biotecnologia, Porto, Portugal, and would also like to thank the scientific collaboration under the FCT project UIDB/50016/2020.
dc.identifier.doi10.1016/j.fbio.2024.104818
dc.identifier.issn2212-4292
dc.identifier.issn2212-4306
dc.identifier.scopus2-s2.0-85200726537
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.fbio.2024.104818
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22802
dc.identifier.volume61
dc.identifier.wosWOS:001293077800001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofFood Bioscience
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectColostrum
dc.subjectDiseases
dc.subjectBioactive components
dc.subjectImmune
dc.subjectLactoferrin
dc.subjectBioprocessing
dc.titleRole of bovine colostrum against various diseases
dc.typeArticle

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