Eosinophilic bronchitis without asthma

Basit Öğe Kaydı
dc.authoridGonlugur, Ugur/0000-0001-8720-2788
dc.contributor.authorGonlugur, Ugur
dc.contributor.authorGonlugur, Tanseli Efeoglu
dc.date.accessioned2025-01-27T20:38:56Z
dc.date.available2025-01-27T20:38:56Z
dc.date.issued2008
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground: Eosinophilic bronchitis without asthma causes chronic coughs without the physiologic features of asthma. The aim of this study was to review the clinical features, pathogenesis, diagnosis, treatment and prognosis of this condition. Methods: The current literature was reviewed using Pubmed for all studies published in the English language using the search term 'eosinophilic bronchitis'. Results: Eosinophilic bronchitis presents as normal spirometry, without evidence of airway hyperresponsiveness, and normal peak expiratory flow variability. When compared with asthma, mast cell recruitment to the superficial airways and mast cell activation appear to be a feature of eosinophilic bronchitis. In contrast, mast cell infiltration in the smooth muscle is significantly higher in asthma patients than in either eosinophilic bronchitis patients or healthy control subjects. In this condition, the absence of high IL-13 expression can contribute to the normal airway reactivity. The cough usually responds well to inhaled corticosteroids but dose and duration of treatment remain unclear. The condition can be transient, episodic or persistent unless treated, and occasionally, patients may require long-term treatment with oral corticosteroids. Conclusions: The condition is an important cause of chronic coughs which are corticosteroid responsive. The study of eosinophilic bronchitis suggests that eosinophil-dependent mechanisms are generally not important in the pathogenesis of asthma. Copyright (C) 2008 S. Karger AG, Basel.
dc.identifier.doi10.1159/000128580
dc.identifier.endpage5
dc.identifier.issn1018-2438
dc.identifier.issn1423-0097
dc.identifier.issue1
dc.identifier.pmid18446047
dc.identifier.scopus2-s2.0-49749144070
dc.identifier.scopusqualityQ2
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.1159/000128580
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23810
dc.identifier.volume147
dc.identifier.wosWOS:000258707700001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherKarger
dc.relation.ispartofInternational Archives of Allergy and Immunology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjecteosinophil leukocytes
dc.subjectbronchitis
dc.subjectasthma
dc.subjecteosinophilic inflammation
dc.titleEosinophilic bronchitis without asthma
dc.typeReview Article

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu