Quercetin associated with dimethylsulfoxide has a curative effect on experimental colon anastomosis injury

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dc.authoridEDREMITLIOGLU, MUSTAFA/0000-0002-0510-9852
dc.authoridDemir, Ufuk/0000-0002-0020-1633
dc.contributor.authorDemir, Ufuk
dc.contributor.authorEdremitlioglu, Mustafa
dc.contributor.authorKanda, Emel
dc.contributor.authorSehitoglu, Muserref Hilal
dc.contributor.authorKilinc, Nihal
dc.date.accessioned2025-01-27T20:24:59Z
dc.date.available2025-01-27T20:24:59Z
dc.date.issued2020
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPurpose: To examine the effects of quercetin on healing of experimental colon anastomosis injury in early and late period. Methods: Eighty male Wistar-Albino rats were divided into 8 groups. For all groups, left colons of the rats were resected and for the rest end-to-end anastomosis was performed. Two of the groups for which the experiment protocol was ended on the 3rd and 7th day following the anastomosis were not administered with either quercetin or dimethylsulfoxide DMSO, whereas two other groups were administered with DMSO only, and four other groups were administered with quercetin dissolved in DMSO in doses of 20 and 100 mg/kg during the protocol. At the end of the study, anastomosis line was resected, histopathological evaluation was performed and bursting pressure, malondialdehyde, superoxide dismutase, catalase, and hydroxyproline levels were measured. Results: Quercetin significantly increased hydroxyproline, superoxide dismutase, catalase levels, histopathological healing score, bursting pressure values and decreased malondialdehyde level in early period. It also significantly increased superoxide dismutase, catalase, and hydroxyproline levels and decreased malondialdehyde level in late period. Conclusion: it was seen that quercetin speeds up the injury healing process and reveals an antioxidant effect, specifically in early period.
dc.description.sponsorshipCanakkale Onsekiz Mart University Scientific Research Projects Coordination (Unit) [TSA-2014-187]
dc.description.sponsorshipCanakkale Onsekiz Mart University Scientific Research Projects Coordination (Unit. Project No: TSA-2014-187)
dc.identifier.doi10.1590/s0102-865020200060000002
dc.identifier.issn0102-8650
dc.identifier.issn1678-2674
dc.identifier.issue6
dc.identifier.pmid32667589
dc.identifier.scopus2-s2.0-85088250510
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1590/s0102-865020200060000002
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22403
dc.identifier.volume35
dc.identifier.wosWOS:000550591300001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherActa Cirurgica Brasileira
dc.relation.ispartofActa Cirurgica Brasileira
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectQuercetin
dc.subjectAnastomosis
dc.subjectSurgical
dc.subjectAntioxidants
dc.subjectRats
dc.titleQuercetin associated with dimethylsulfoxide has a curative effect on experimental colon anastomosis injury
dc.typeArticle

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