Effect of Systemically Used Anti-Tumor Necrosis Factor- Medication on the Corneal Epithelium and Stroma of Patients with Ankylosing Spondylitis

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dc.contributor.authorArikan, Sedat
dc.contributor.authorGokmen, Ferhat
dc.contributor.authorErsan, Ismail
dc.contributor.authorAkbal, Ayla
dc.contributor.authorResorlu, Hatice
dc.contributor.authorGencer, Baran
dc.contributor.authorAli Tufan, Hasan
dc.date.accessioned2025-01-27T20:47:37Z
dc.date.available2025-01-27T20:47:37Z
dc.date.issued2017
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPurpose: To evaluate the effect of systemically used anti-tumor necrosis factor alpha (TNF-alpha) medication on the thickness of corneal epithelium and stroma in patients with ankylosing spondylitis (AS). Methods: A total of 125 eyes of 69 participants were included in this retrospective study of three groups: healthy participants (Group 1), AS patients receiving anti-TNF-alpha medication (Group 2), and AS patients receiving a nonsteroidal anti-inflammatory medication (Group 3). Results: According to anterior segment optical coherence tomography, the mean thickness of the corneal epithelium was significantly thicker in Group 2 than in Group 3 (51.6 +/- 3.2 mu m versus 50.4 +/- 3 mu m, p = 0.01), as was that of the stroma (475 +/- 33 mu m versus 443 +/- 29 mu m, p = 0.002). Conclusions: Anti-TNF-alpha medication and/or avoidance of nonsteroidal anti-inflammatory drugs could improve the thickness of both the corneal epithelium and stroma in AS patients.
dc.identifier.doi10.3109/09273948.2015.1107592
dc.identifier.endpage228
dc.identifier.issn0927-3948
dc.identifier.issn1744-5078
dc.identifier.issue2
dc.identifier.pmid26731089
dc.identifier.scopus2-s2.0-84953208390
dc.identifier.scopusqualityQ1
dc.identifier.startpage223
dc.identifier.urihttps://doi.org/10.3109/09273948.2015.1107592
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24985
dc.identifier.volume25
dc.identifier.wosWOS:000399740900012
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Inc
dc.relation.ispartofOcular Immunology and Inflammation
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectSnkylosing spondylitis
dc.subjectAS-OCT
dc.subjectanti-TNF-alpha medication
dc.subjectNSAIDs
dc.subjectcorneal epithelium
dc.subjectcorneal stroma
dc.titleEffect of Systemically Used Anti-Tumor Necrosis Factor- Medication on the Corneal Epithelium and Stroma of Patients with Ankylosing Spondylitis
dc.typeArticle

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